Biomolecular Sciences and Precision Medicine in Vascular Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 596

Special Issue Editor

Special Issue Information

Dear Colleagues,

Vascular disease (VD) is the leading cause of morbidity and mortality worldwide. VD includes atherosclerotic manifestations such as peripheral artery disease (PAD), acute limb ischemia (ALI), and carotid stenosis (CS); central and peripheral aneurysms; chronic venous disease (CVD) and venous thromboembolism (VTE); and vascular wounds such as diabetic foot ulcer (DFU), venous leg ulcer (VLU), and arterial leg ulcer (ALU).

Novel biomarkers related to molecular sciences research and application may be used as screening and risk-assessment tools to identify patients who are vulnerable to VD in the new context of Precision Medicine. In fact, the recent experimental technical progress related to biology, chemistry, and molecular medicine has allowed scientists to find effective biomarkers to assess and identify high-risk individuals, ensure prompt and accurate diagnosis, and follow up on patients who have undergone medical treatment and/or vascular and endovascular surgery procedures.

Currently, the complex approach to illness considers biology and medicine to be connected to social and molecular determinants of health that are strictly related to molecular sciences and biomarkers.

For this Special Issue, we invite investigators to contribute original research and review papers that provide new insights into the biomolecular mechanisms of VD, as well as work on new diagnostic and prognostic tools/biomarkers related to therapeutic strategies.

Prof. Dr. Raffaele Serra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision medicine
  • vascular disease
  • vascular surgery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 576 KB  
Article
Molecular Drivers of Vascular Adaptation in Young Athletes: An Integrative Analysis of Endothelial, Metabolic and Lipoprotein Biomarkers
by Jonas Haferanke, Lisa Baumgartner, Maximilian Dettenhofer, Stefanie Huber, Frauke Mühlbauer, Tobias Engl, Paulina Wasserfurth, Karsten Köhler, Renate Oberhoffer, Thorsten Schulz and Sebastian Freilinger
Biomolecules 2025, 15(12), 1726; https://doi.org/10.3390/biom15121726 - 11 Dec 2025
Viewed by 200
Abstract
Adolescence is a critical window for cardiovascular (CV) development, yet the molecular drivers of vascular adaptation to regular exercise in youth remain poorly understood. This cross-sectional study assessed vascular structure and function alongside endothelial, metabolic, and lipoprotein biomarkers in 203 healthy young athletes [...] Read more.
Adolescence is a critical window for cardiovascular (CV) development, yet the molecular drivers of vascular adaptation to regular exercise in youth remain poorly understood. This cross-sectional study assessed vascular structure and function alongside endothelial, metabolic, and lipoprotein biomarkers in 203 healthy young athletes (aged 10–16). Vascular phenotyping included carotid intima-media thickness (IMT), pulse wave velocity, and carotid deformation indices (strain, strain rate). Circulating nitric oxide (NO), endothelin-1, free triiodothyronine (fT3), leptin, low-density lipoprotein, and high-density lipoprotein were analyzed. Associations were examined using hierarchically adjusted multivariable linear regression, mediation and moderation were tested and sex-stratified/matched analyses were conducted. While training volume was not associated with endothelial markers, leptin was correlated positively with NO and negatively with diastolic strain rate, suggesting dual vascular actions. fT3 was inversely associated with IMT, indicating a potential protective role in vascular remodeling. Lipoprotein profiles showed no independent associations with vascular parameters. Hemodynamic load, particularly systolic blood pressure, emerged as the dominant determinant of arterial stiffness. Sex-specific differences across biomarkers and vascular indices support a multifactorial model: in active youth, vascular phenotype reflects hemodynamics, body composition, and endocrine–metabolic signals more than training; longitudinal mechanistic studies should clarify causal pathways and guide individualized cardiovascular risk profiling. Full article
(This article belongs to the Special Issue Biomolecular Sciences and Precision Medicine in Vascular Disease)
Show Figures

Figure 1

Back to TopTop