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Biomolecules
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26 May 2026
Biomolecules | Highly Cited Papers in 2025–2026 in the “Molecular Biology” Section


As all articles published in our journal are open access, you have free, unlimited access to the full text. We invite you to read our most highly cited papers published in 2025 and 2026, which are listed below:

1. “The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease”
by Paola Zanfardino, Alessandro Amati, Mirko Perrone and Vittoria Petruzzella
Biomolecules 2025, 15(3), 433; https://doi.org/10.3390/biom15030433
Full text available online: https://www.mdpi.com/2218-273X/15/3/433

2. “Pathological and Inflammatory Consequences of Aging”
by Mario García-Domínguez
Biomolecules 2025, 15(3), 404; https://doi.org/10.3390/biom15030404
Full text available online: https://www.mdpi.com/2218-273X/15/3/404

3. “Calcium Signaling Dynamics in Vascular Cells and Their Dysregulation in Vascular Disease”
by Chang Dai and Raouf A. Khalil
Biomolecules 2025, 15(6), 892; https://doi.org/10.3390/biom15060892
Full text available online: https://www.mdpi.com/2218-273X/15/6/892

4. “Interplay Between Vascular Dysfunction and Neurodegenerative Pathology: New Insights into Molecular Mechanisms and Management”
by Avanthika Mekala and Hongyu Qiu
Biomolecules 2025, 15(5), 712; https://doi.org/10.3390/biom15050712
Full text available online: https://www.mdpi.com/2218-273X/15/5/712

5. “The Role of IL-6 in Ischemic Stroke”
by Hanna Pawluk, Alina Woźniak, Agnieszka Tafelska-Kaczmarek, Agnieszka Kosinska, Mateusz Pawluk, Krzysztof Sergot, Renata Grochowalska and Renata Kołodziejska
Biomolecules 2025, 15(4), 470; https://doi.org/10.3390/biom15040470
Full text available online: https://www.mdpi.com/2218-273X/15/4/470

6. “Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process?”
by Laura Sabatino and Cristina Vassalle
Biomolecules 2025, 15(3), 361; https://doi.org/10.3390/biom15030361
Full text available online: https://www.mdpi.com/2218-273X/15/3/361

7. “β-Catenin: A Key Molecule in Osteoblast Differentiation”
by Edyta Wróbel, Piotr Wojdasiewicz, Agnieszka Mikulska and Dariusz Szukiewicz
Biomolecules 2025, 15(7), 1043; https://doi.org/10.3390/biom15071043
Full text available online: https://www.mdpi.com/2218-273X/15/7/1043

8. “Circadian Biomarkers in Humans: Methodological Insights into the Detection of Melatonin and Cortisol”
by Cene Skubic, Urša Zevnik, Katarina Nahtigal, Leja Dolenc Grošelj and Damjana Rozman
Biomolecules 2025, 15(7), 1006; https://doi.org/10.3390/biom15071006
Full text available online: https://www.mdpi.com/2218-273X/15/7/1006

9. “Unravelling the Connection Between Energy Metabolism and Immune Senescence/Exhaustion in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome”
by Jente Van Campenhout, Yanthe Buntinx, Huan-Yu Xiong, Arne Wyns, Andrea Polli, Jo Nijs, Joeri L. Aerts, Thessa Laeremans and Jolien Hendrix
Biomolecules 2025, 15(3), 357; https://doi.org/10.3390/biom15030357
Full text available online: https://www.mdpi.com/2218-273X/15/3/357

10. “Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation”
by Marta Pace, Chiara Giorgi, Giorgia Lombardozzi, Annamaria Cimini, Vanessa Castelli and Michele d’Angelo
Biomolecules 2025, 15(8), 1115; https://doi.org/10.3390/biom15081115
Full text available online: https://www.mdpi.com/2218-273X/15/8/1115

11. “Immunohistochemical Detection of PIEZO Ion Channels in the Human Carotid Sinus and Carotid Body”
by Elda Alba, Yolanda García-Mesa, Ramón Cobo, Patricia Cuendias, José Martín-Cruces, Iván Suazo, Graciela Martínez-Barbero, José A. Vega, Olivia García-Suárez and Teresa Cobo
Biomolecules 2025, 15(3), 386; https://doi.org/10.3390/biom15030386
Full text available online: https://www.mdpi.com/2218-273X/15/3/386

12. “Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model”
by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru and Lucian Hritcu
Biomolecules 2025, 15(1), 138; https://doi.org/10.3390/biom15010138
Full text available online: https://www.mdpi.com/2218-273X/15/1/138

13. “Oxidative DNA Damage and Repair Dynamics in Multiple Sclerosis: Insights from Comet Assay Kinetics, Base Excision Repair Gene Expression, and Genotype Analysis”
by Beata Filipek, Anna Macieja, Aleksandra Binda, Rafal Szelenberger, Leslaw Gorniak, Elzbieta Miller, Mariola Swiderek-Matysiak, Mariusz Stasiolek, Ireneusz Majsterek and Tomasz Poplawski
Biomolecules 2025, 15(6), 756; https://doi.org/10.3390/biom15060756
Full text available online: https://www.mdpi.com/2218-273X/15/6/756

14. “Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling”
by Ming Tong, Camilla Homans, William Pelit, Busra Delikkaya and Suzanne M. de la Monte
Biomolecules 2025, 15(3), 413; https://doi.org/10.3390/biom15030413
Full text available online: https://www.mdpi.com/2218-273X/15/3/413

15. “Functional Analysis of Direct In Vitro Effect of Phosphorylated Tau on Mitochondrial Respiration and Hydrogen Peroxide Production”
by Zdeněk Fišar and Jana Hroudová
Biomolecules 2025, 15(4), 495; https://doi.org/10.3390/biom15040495
Full text available online: https://www.mdpi.com/2218-273X/15/4/495

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