Research Advances on the Protein-Protein Interactions and Development of Therapeutics
A special issue of BioMedInformatics (ISSN 2673-7426).
Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 3719
Special Issue Editor
Special Issue Information
Dear Colleagues,
Several diseases are the result of aberrant protein–protein interactions involving endogenous or pathogen-derived proteins. A blockade of such undesirable interactions has proven clinical benefits and has been identified as a prime target for the drug design. Due to the flat and wide interface, some protein targets are certainly inappropriate for the development of small drug molecules; in addition, production of monoclonal antibodies against such protein molecules is expensive and challenging due to the short half-life of antibodies. Hence, applying peptide molecules to block undesirable protein–protein interactions would be advantageous. In the modern proteomic era, protein structure can be predicted from amino acid sequence; this leads to the development of novel proteins with pre-determined structure and function.
BioMedInformatics is a peer-reviewed journal publishing articles in the field of applied sciences. In this Special Issue, we invite authors to submit their studies on protein–protein interaction and the development of therapeutics using various computational methodssuch as protein structure prediction, molecular docking, molecular modelling, molecular dynamics simulation, and free energy calculations. Research themes include treatments for cancer and neurological disorders, alternatives to overcome antibiotic resistance, and drugs to treat zoonotic infectious diseases.
Dr. Ravindra Thakkar
Guest Editor
Manuscript Submission Information
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Keywords
- molecular dynamics simulation of biomolecules
- free energy calculation
- molecular docking
- binding assay for protein–protein interactions
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