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Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease

1
Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83209, USA
2
Whitman College, Walla Walla, WA 99362, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Jessika Bertacchini
Biomedicines 2021, 9(5), 551; https://doi.org/10.3390/biomedicines9050551
Received: 23 March 2021 / Revised: 5 May 2021 / Accepted: 9 May 2021 / Published: 14 May 2021
(This article belongs to the Special Issue Bone Tissue Regeneration: Biology and Strategies)
The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. With a better understanding of the cellular pathophysiology associated with the more common bone diseases, these diseases can be scaled down to a more throughput way to test therapies that can reverse the cellular pathophysiology. In this review, we will discuss the potential of 3D bioprinting of bone tissue in the following disease states: osteoporosis, Paget’s disease, heterotopic ossification, osteosarcoma, osteogenesis imperfecta, and rickets disease. The development of these 3D bioprinted models will allow for the advancement of novel therapy testing resulting in possible relief to these chronic diseases. View Full-Text
Keywords: 3D bioprinting; bone; osteoporosis; heterotopic ossification; osteosarcoma; Paget’s disease; osteogenesis imperfecta; rickets disease 3D bioprinting; bone; osteoporosis; heterotopic ossification; osteosarcoma; Paget’s disease; osteogenesis imperfecta; rickets disease
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MDPI and ACS Style

Pavek, A.; Nartker, C.; Saleh, M.; Kirkham, M.; Khajeh Pour, S.; Aghazadeh-Habashi, A.; Barrott, J.J. Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease. Biomedicines 2021, 9, 551. https://doi.org/10.3390/biomedicines9050551

AMA Style

Pavek A, Nartker C, Saleh M, Kirkham M, Khajeh Pour S, Aghazadeh-Habashi A, Barrott JJ. Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease. Biomedicines. 2021; 9(5):551. https://doi.org/10.3390/biomedicines9050551

Chicago/Turabian Style

Pavek, Adriene, Christopher Nartker, Maamoon Saleh, Matthew Kirkham, Sana Khajeh Pour, Ali Aghazadeh-Habashi, and Jared J. Barrott. 2021. "Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease" Biomedicines 9, no. 5: 551. https://doi.org/10.3390/biomedicines9050551

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