Special Issue "Vasoactive Intestinal Peptide (VIP) and Related Signaling Molecules in Health and Disease"
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 1753
Interests: vasoactive intestinal peptide (VIP); G protein-coupled receptors (GPCR); microbiota; metabolism; gluconeogenesis; intestinal homeostasis; fatty acid metabolism; glucose metabolism; obesity; type 2 diabetes (T2D); immune function
Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide with a broad expression profile, regulating diurnal feeding behavior, metabolism, and immunity. VIP is delivered by the peripheral nervous system to numerous organs, including the mucosa-associated lymphoid tissues of the pulmonary and gastrointestinal tract. VIP signals with a high affinity (Kd = 1 nM) through at least two endogenous G protein-coupled receptors (GPCR), called vasoactive intestinal peptide/pituitary adenylyl cyclase activating polypeptide (VPAC) 1 and VPAC2. A third low affinity receptor (Kd = 1 μM), termed PAC1, also binds VIP. VIP is part of a larger family of biologically active peptides that includes pituitary adenylate cyclase activating polypeptide (PACAP), which shares a 68% amino acid identity with VIP and binds all three receptors (PAC1, VPAC1, and VPAC2) with a high affinity (≈1 nM Kd).
I invite my colleagues in this field to contribute to this Special Issue on VIP/PACAP and its related peptides in health and disease by providing research articles or relevant topic reviews. This Special Issue will act as an important depository for novel and review research summaries in the VIP/PACAP family of signaling peptides in health and disease.
Prof. Dr. Glenn P. Dorsam
Manuscript Submission Information
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- vasoactive intestinal peptide (VIP)
- G protein-coupled receptors (GPCR)
- pituitary adenylate cyclase activating polypeptide (PACAP)
- secretin (SCT)
- peptide histidine methionine (PHM)
- PACAP-related peptide (PRP)
- glucagon (GCG)