Special Issue "Advances in Proteomics Methods"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 December 2013).
Interests: Biomarkers of human disease and proteomics
Interests: inflammatory diseases; biomarker discovery and validation; post-translational modifications
The ultimate goals of proteomics methods are: Whole proteome coverage at high sensitivity and with rapid throughput and whole protein coverage both structural and functional.
Currently gel- and liquid chromatography based protein and peptide separation combined with mass spectrometry form the basis of most proteomics methods and huge progress is being made in reaching the goal of ‘routine’ whole proteome coverage and the analysis of post-translational modifications. Recent developments have been such that the field of proteomics is now beginning to impact on our understanding of disease pathogenesis and has exciting opportunities in personalised medicine. Notably, improved mass spectrometry based technologies combined with developments in chemical strategies continue to play a leading role in these advances. However, many challenges remain – not least in how to improve ‘protein coverage, increase the sensitivity and sophistication of protein analysis and reach the level of throughput that many potential applications require. At the same time the quantity of data produced and its variable quality is presenting new demands – both for the handling and reliable interpretation of the data. New methods for data storage, sharing, analysis and re-analysis are in development and much needed. This special issue aims to draw together original research articles and reviews on current and projected advances in diverse proteomics methods.
Submissions covering the following topics will be welcomed:
Sample preparation methods (LCM, protein enrichment);
Label-free and isotopic labeling strategies for LC-MS/MS;
Role of miniaturisation/amplification strategies (Achieving sensitivity with smaller/limited samples);
Protein recognition (antibody, aptamer) based approaches;
Whole proteome coverage;
Software development for handling and interpreting MS data;
MRM: development and applications;
Post-translational modifications: to phosphorylation and beyond;
Advances in MS instrumentation;
Proteomics databases: data storage and sharing, data re-analysis;
Statistical approaches and novel algorithms;
Methods and instrumentation for taking proteomics to clinical utility
Please note this is not an exhaustive list
Prof. Stephen R. Pennington
Dr. Lisa Staunton
Dr. David S. Gibson
Manuscript Submission Information
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