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Biology 2014, 3(1), 22-38;

Contemporary Network Proteomics and Its Requirements

School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, Singapore
Department of Physiology, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore
Neuroepigenetics Laboratory, Growth, Development and Metabolism Programme, Singapore Institute for Clinical Sciences, Agency for Science and Technology (A*STAR), Singapore 117609, Singapore
Author to whom correspondence should be addressed.
Received: 12 November 2013 / Revised: 15 December 2013 / Accepted: 16 December 2013 / Published: 20 December 2013
(This article belongs to the Special Issue Advances in Proteomics Methods)
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The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis. View Full-Text
Keywords: proteomics; networks; systems biology; bioinformatics proteomics; networks; systems biology; bioinformatics

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Goh, W.W.B.; Wong, L.; Sng, J.C.G. Contemporary Network Proteomics and Its Requirements. Biology 2014, 3, 22-38.

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