Novel Findings in Fatty Acids and Inflammation
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 5063
Special Issue Editors
Interests: fatty acids; inflammatory disease; lipid mediators
Special Issue Information
Dear colleagues,
The role of fatty acids (FA) in inflammation is complex, with many unresolved issues regarding nutrition, synthesis of lipid mediators from FA, and the pro- or anti-inflammatory roles of particular FA. Traditionally, n-3 polyunsaturated FA (PUFA) have been classified as beneficial and n-6 PUFA as pro-inflammatory, and while arachidonic acid (20:4n-6) is the precursor of pro-inflammatory mediators, its increased intake per se can fail to increase the concentrations of inflammatory markers, but may still inhibit the pro-resolving effects of n-3 PUFA. While theoretically beneficial, n-3 PUFA consumption at feasible levels does not necessarily initiate anti-inflammatory effects in humans. In overt inflammation, such as rheumatoid arthritis, the balance of inflammatory to anti-inflammatory FA and their derivatives shows both local and systemic changes. Moreover, low-grade inflammatory diseases that could entail obesity have received well-deserved attention. Among the hypotheses behind the inflammatory effects of obesity is that the fat-overloaded adipocytes could directly activate the immune pathogen-sensors that cause chronic inflammation. Emerging research on extracellular vesicles suggests that there might be one signal from the adipocytes to other organ systems. In this Special Issue, we welcome contributions associated with these fields of FA research, including dietetics, therapeutic interventions, genetics, and studies in molecular biology.
Prof. Petteri Nieminen
Dr. Anne Mari Mustonen
Guest Editors
Manuscript Submission Information
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Keywords
- extracellular vesicles
- fatty acids
- inflammatory disease
- lipid mediators
- MUFA
- PUFA
- SFA
- SPM
