Bioinformatic Analysis of Gene Transcription Regulation
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Bioinformatics".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2449
Special Issue Editor
Interests: bioinformatics; computational biology; regulation of transcriptions; regulatory elements; bulk and single-cell transcriptomics; genetics and breeding
Special Issue Information
Dear Colleagues,
In organisms, disorder and abnormal transcription in the regulation of genes often results in diseases and phenotypic defects. Gene transcriptions are complex multi-level processes controlled by cis- and trans-regulatory elements (e.g., promoters, enhancers, insulators, silencers, poly (dA:dT) tracts and other regulatory elements), as well as regulatory RNAs such as miRNAs, lncRNAs and circRNAs. However, current knowledge of these regulatory elements and RNAs is still limited. Thanks to the success of the ENCODE, FANTOM and GTEX Projects, we know that most DNA is not “junk” and has actual regulatory functions. Using novel biotechnologies such as RNA sequencing, single-cell multi-omics, ChIA-PET and Hi-C chromosome conformation capture, more regulatory elements and RNAs are bioinformatically characterized for transcribed regions and transcript isoforms, which are recognized by RNA-binding proteins, DNA-binding proteins, transcription factor-binding regions that harbour specific histone modifications, DNA methylations, open chromatins, and 3D chromatin interactions in different cellular types and tissues.
It is important to note the advances in, approaches to and pipelines for the bioinformatic analysis of gene transcription regulation to reveal more regulatory elements and regulatory RNAs. We are pleased to invite authors to submit manuscripts on the regulatory transcriptions of genes with bioinformatic analysis on genomics, epigenomics or transcriptomics, as well as single-cell multi-omics, in different cellular types and tissues. In this Special Issue, original articles and reviews on bioinformatic research or tools are welcome. Research areas may include (but are not limited to): RNA-binding proteins, DNA-binding proteins, transcription factor-binding regions, specific histone modifications, DNA methylations, open chromatin and 3D chromatin interactions, and regulatory RNAs.
We look forward to receiving your contributions.
Dr. Xiaolong Yuan
Guest Editor
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Keywords
- bioinformatic analysis
- regulation of transcriptions
- regulatory elements
- regulatory RNAs
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