RNA Biology and mRNA in Diseases

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 774

Special Issue Editor

College of Life and Health Sciences, Northeastern University, Shenyang 110167, China
Interests: embryo development; genome editing; epigenetics; cancer; stem cells; somatic cell nuclear transfer; oxidative stress; pig; natural products; phase separation

Special Issue Information

Dear Colleagues,

The understanding of RNA biology and the development of mRNA-based therapeutics have significantly advanced the field of disease treatment, offering promising solutions for a wide range of medical conditions. This Special Issue aims to gather pioneering research on the mechanisms of RNA regulation and the innovative applications of mRNA therapeutics in disease management. We encourage submissions that investigate the synthesis, transportation, modification, translation, and decoy degradation of RNA and explore the design, synthesis, and delivery of mRNA-based vaccines and drugs, as well as their applications in treating diseases such as cancer, infectious diseases, and genetic disorders. We are particularly interested in studies that demonstrate the novel approach to enhance the efficacy of mRNA-based therapeutics in animal or laboratory settings, including those reporting on gene expression, immune responses, and therapeutic outcomes. We invite original research articles and comprehensive reviews that focus on, but are not limited to, stress granules, RNA fate, RNA-based vaccines, targeted mRNA delivery systems, and the latest advancements in RNA technology, such as CRISPR/Cas13, RNA labels, and biosensors. This Special Issue aims to provide a platform for researchers to share their findings and contribute to the growing body of knowledge in RNA biology and mRNA-based therapeutics.

Dr. Yongye Huang
Guest Editor

Manuscript Submission Information

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Keywords

  • stress granule
  • cRISPR/Cas13
  • vaccine
  • mRNA drug
  • antisense oligonucleotides
  • RNA methylation
  • microRNA
  • long non-coding RNA
  • RNA binding
  • RNA activation
  • circular RNA
  • fluorescent RNA
  • cell surface RNA
  • cancer
  • neurodegenerative disease

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Published Papers (1 paper)

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Review

28 pages, 1358 KiB  
Review
Biomolecules Interacting with Long Noncoding RNAs
by Hidenori Tani
Biology 2025, 14(4), 442; https://doi.org/10.3390/biology14040442 - 19 Apr 2025
Viewed by 185
Abstract
This review explores the complex interactions between long noncoding RNAs (lncRNAs) and other biomolecules, highlighting their pivotal roles in gene regulation and cellular function. LncRNAs, defined as RNA transcripts exceeding 200 nucleotides without encoding proteins, are involved in diverse biological processes, from embryogenesis [...] Read more.
This review explores the complex interactions between long noncoding RNAs (lncRNAs) and other biomolecules, highlighting their pivotal roles in gene regulation and cellular function. LncRNAs, defined as RNA transcripts exceeding 200 nucleotides without encoding proteins, are involved in diverse biological processes, from embryogenesis to pathogenesis. They interact with DNA through mechanisms like triplex structure formation, influencing chromatin organization and gene expression. LncRNAs also modulate RNA-mediated processes, including mRNA stability, translational control, and splicing regulation. Their versatility stems from their forming of complex structures that enable interactions with various biomolecules. This review synthesizes current knowledge on lncRNA functions, discusses emerging roles in development and disease, and evaluates potential applications in diagnostics and therapeutics. By examining lncRNA interactions, it provides insights into the intricate regulatory networks governing cellular processes, underscoring the importance of lncRNAs in molecular biology. Unlike the majority of previous reviews that primarily focused on individual aspects of lncRNA biology, this comprehensive review uniquely integrates structural, functional, and mechanistic perspectives on lncRNA interactions across diverse biomolecules. Additionally, this review critically evaluates cutting-edge methodologies for studying lncRNA interactions, bridges fundamental molecular mechanisms with potential clinical applications, and highlights their potential. Full article
(This article belongs to the Special Issue RNA Biology and mRNA in Diseases)
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