Special Issue "Extracellular Vesicles: Multifaceted Biological Nanoparticles in Health and Disease"
Deadline for manuscript submissions: 30 September 2022 | Viewed by 10565
Cells release vesicles of different sizes throughout life until their death. The mode of vesicle genesis dictates their size, content, function, and perhaps clues to their identification. Multivesicular endosomes-originated vesicles named exosomes are the smallest (35-150 nm) extracellular vesicles known to date, making their purification somewhat challenging. Once purified, exosomes can be easily characterized due to their association with specific marker proteins, their appearance under transmission electron microscope, and density. Originally described as “vesicles filled with unwanted cellular proteins” for disposal out of the maturing reticulocytes, exosomes have now become an important entity in the intercellular communication field. Exosomes exert their influence on gene expression of cells internalizing them. Release of exosomes by parent cells and the ability of recipient cells to internalize exosomes is key to cell-cell communication. Internalized exosomes modulate physiology of recipient cells during all stages of life ranging from normal to senescence including a diseased state. Exosome unique cargo of proteins, lipids, metabolites, and nucleic acids offers opportunities to employ them for identification of biomarkers associated with normal physiology and importantly as promising diagnostic tools in clinical practice. Exosomes can be employed for targeted therapeutic treatments by loading them with appropriate proteins and nuclei acids to alter gene expression in defined recipient cells. Exosomes present endless prospects in life sciences.
Dr. Meena Kumari
Manuscript Submission Information
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- extracellular vesicles and exosomes
- isolation and characterization
- biological activity in development, differentiation, health and disease
- therapeutic applications
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.