Special Issue "Biomarkers and Immunotherapeutic Targets in Glioblastoma"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 31 May 2021.
Glioblastoma, also called GBM, the most aggressive type of primary brain tumor, makes up about 15% of all brain tumors and is projected to be diagnosed in nearly 210,000 people globally each year. Despite aggressive treatment with surgery, radiation, and chemotherapy, GBM remains an incurable tumor with a median survival of only 15 months. Immunotherapy has seen great success in the treatment of various types of cancer, from melanoma to lung, breast, colorectal, kidney, and even some brain cancers. Accordingly, this type of therapy may give us a lot of hope and act as the future of GBM treatment. To date, GBM has not been among immunotherapy success stories yet due to several obstacles including the highly immunosuppressive nature of GBM and the limitations of the immune response in the central nervous system. Currently, a diverse set of biomarkers such as different checkpoint molecules have already been well investigated and implicated as potential immunotherapeutic targets and prognostic indicators in some types of cancers. Therefore, understanding the biomarkers for appropriate patient selection as well as tumor progression are necessary for implementation of immunotherapy for GBM. Additionally, the combination of immune therapies driven by these biomarkers would be the key for the future of immunotherapy for GBM. This Special Issue welcomes the submission of original research and review manuscripts focusing on biomarkers of interest for the diagnosis, therapy, an theranostics of GBM, but also on the specific technologies employed in their identification and targeting, helping us to achieve a realistic overview of this exciting and interdisciplinary field of biomedical research. It is envisioned that this Special Issue will help readers to become more familiar with advances in the discovery and development of effective immunotherapeutic treatments for the devastating GBM.
Dr. Jiao Wang
Dr. Sandro Matosevic
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