Role of Fibroblasts in Tissue Regeneration and Fibrosis
A Special Issue of Biology (ISSN 2079-7737) belonging to the section "Medical Biology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 3091
Editor
2. SECIHTI-Facultad de Medicina y Cirugía, Universidad Autónoma Benito Juárez de Oaxaca, Ex Hacienda de Aguilera S/N, Sur, San Felipe del Agua, Oaxaca 68020, Mexico
Interests: fibroblast; bioinformatics; extracelular vesicles; pulmonary fibrosis; inflammation and repurposed drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fibroblasts play a central role in tissue repair, regeneration, and fibrosis by regulating extracellular matrix remodeling, inflammatory responses, and cellular crosstalk within the tissue microenvironment. Increasing evidence highlights fibroblasts as highly heterogeneous and plastic cells whose context-dependent activation determines whether tissue healing resolves or progresses toward chronic fibrosis. Understanding the molecular and cellular mechanisms governing fibroblast behavior is therefore critical for elucidating fundamental biological processes and identifying novel therapeutic targets.
This Special Issue, “Role of Fibroblasts in Tissue Regeneration and Fibrosis,” aims to bring together recent advances in fibroblast biology, focusing on signaling pathways, regulatory networks, and intercellular communication involved in physiological regeneration and pathological fibrotic remodeling. We seek submissions emphasizing mechanistic insights, experimental models, and integrative approaches to tissue homeostasis and disease.
We welcome original research articles and reviews addressing fibroblast function across organs and disease contexts, including emerging omics-based and systems biology approaches. Suggested themes include the following:
- Fibroblast heterogeneity and lineage specification;
- Fibroblast activation, senescence, and plasticity;
- Fibroblast–immune cell interactions;
- Extracellular matrix remodeling and mechanotransduction;
- Single-cell and spatial omics of fibroblast populations;
- Fibroblasts in organ-specific fibrosis (lung, liver, kidney, heart, skin);
- Signaling pathways regulating fibroblast fate (e.g., TGF-β, Wnt, Hippo);
- Therapeutic strategies targeting fibroblast-driven fibrosis.
We look forward to receiving your contributions.
Dr. Rafael Baltierrez-Hoyos
Guest Editor
Manuscript Submission Information
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Keywords
- fibroblasts
- tissue regeneration
- fibrosis
- cellular heterogeneity
- extracellular matrix
- cell signaling
- mechanotransduction
- omics
- tissue remodeling
- systems biology
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