Effect of Ageing and Inflammation on Immune Regulatory Pathway
A Special Issue of Biology (ISSN 2079-7737) belonging to the section "Immunology".
Deadline for manuscript submissions: 31 December 2027 | Viewed by 589
Editors
Interests: macrophage senescence; mitochondria; SASP; longevity
2. Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA
3. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA
Interests: membrane proteins; proteomics; protein-protein interaction; transporters complex; ADP-ribosylome
Special Issue Information
Dear Colleagues,
Chronic inflammation plays a pivotal role in aging, with each influencing the other negatively. The inflammatory pathway has been shown to be crucial in determining whether aging is exacerbated. Consequently, the regulatory pathways of inflammation are tightly controlled; any dysregulation may lead to adverse biological outcomes known as inflammaging. Furthermore, cellular senescence represents a significant aspect of aging, where its accumulation profoundly impacts the development of both aging and inflammaging. As we age, our cells are increasingly exposed to environmental cues that contribute to mitochondrial damage. Consequently, accumulated damaged mitochondria can serve as a source of stress molecules, which may amplify inflammaging and ultimately lead to chronic inflammation-related diseases, including cancer. Mitochondrial dysfunction is now recognized as a key hallmark driving cellular senescence.
However, our focus extends beyond mitochondrial dysfunction to include other critical hallmarks, such as nutritional deprivation, telomere shortening, DNA damage responses, and loss of proteostasis. A comprehensive understanding of the inflammatory pathway, as mentioned above, could enable us to monitor how our cells undergo senescence and identify candidate pathways for intervention. Naturally occurring aging in organisms is associated with cellular senescence; thus, maintaining cellular senescence homeostasis could support lifespan and longevity. Our Special Issue encompasses a variety of topics ranging from the molecular basis of cellular senescence, cancer in aging, chronic inflammation, mitochondrial biology in senescence, to longevity. However, our scope is not limited to these key events; we also encourage novel insights on aging, chronic inflammation, and longevity.
Dr. Thiranut Jaroonwitchawan
Dr. Pornparn Kongpracha
Guest Editors
Dr. Tanakamol Mahawan
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- cellular senescence
- mitochondria dysfunction
- inflammation
- longevity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
