Molecular Insights into Malignant Cutaneous Adnexal Neoplasms
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 40
Special Issue Editors
Interests: carcinogenesis; metabolic reprogramming; pathology; cutaneous adnexal neoplasms; molecular mechanisms; skin cancer
Special Issue Information
Dear Colleagues,
Malignant cutaneous adnexal neoplasms are rare but clinically significant tumors arising from hair follicles, sebaceous glands, apocrine glands, and eccrine glands. Despite their histologic diversity and aggressive potential, the molecular mechanisms underlying their pathogenesis remain poorly understood compared with more common skin cancers. Recent advances in genomic and transcriptomic profiling have begun to uncover recurrent genetic drivers, including TP53 mutations, PI3K/AKT/mTOR signaling alterations, mismatch repair deficiencies, and aberrations in Hedgehog and Wnt/β-catenin pathways. These findings not only provide insights into tumor initiation and progression but also highlight potential targets for precision medicine.
Given their rarity, malignant adnexal tumors serve as a valuable model to study lineage-specific tumorigenesis, differentiation pathways, and tumor microenvironmental influences. This Special Issue aims to gather contributions focused on the molecular and cellular biology of malignant adnexal neoplasms, including mechanistic studies, molecular classification efforts, and integrative analyses linking genetics, epigenetics, and tumor–stroma interactions. Reviews that synthesize current knowledge and identify future research priorities are also welcome. By bringing together cutting-edge research, this collection seeks to advance our understanding of malignant adnexal neoplasms and shed light on their unique role in skin tumor biology.
We look forward to receiving your contributions.
Dr. Albert Alhatem
Dr. Rosalynn M. Nazarian
Guest Editors
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Keywords
- malignant adnexal neoplasms
- sebaceous carcinoma
- hidradenocarcinoma
- malignant spiradenoma
- trichoblastic carcinoma
- molecular mechanisms
- signal transduction pathways
- tumor microenvironment
- epigenetics
- genomic profiling
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