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Bioengineering
Special Issues
Recent Advancements in Wound Healing and Repair, 2nd Edition
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Recent Advancements in Wound Healing and Repair, 2nd Edition

A Special Issue of Bioengineering (ISSN 2306-5354) belonging to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 2272

Editor

Dr. Wing Sum Siu

E-Mail Website
Guest Editor
Institute of Chinese Medicine, Chinese University of Hong Kong, Hong Kong 999077, China
Interests: bone; mesenchymal stem cell; osteoporosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advancements in wound healing and repair have introduced innovative approaches, paving the way for faster and more effective recovery. These developments encompass the use of bioactive dressings, growth factors, stem cell therapy, and tissue engineering to enhance tissue regeneration and minimize scarring. Emphasizing personalized medicine, researchers are crafting tailored treatment strategies that address the unique needs of each patient.

Following the success of the first edition, this second edition of the Special Issue “Recent Advancements in Wound Healing and Repair” aims to provide a continued and expanded platform for presenting the latest breakthroughs and cutting-edge research in this dynamic field. We invite researchers to contribute original research articles and comprehensive reviews that shed light on novel approaches to accelerate and improve the quality of wound repair.

We encourage the submission of studies focused on:

  • Advanced Wound Care Technologies: The development and application of novel biomaterials, such as smart hydrogels, bioactive dressings, and skin substitutes.
  • Regenerative Medicine: The role of stem cells, growth factors, and exosomes in promoting tissue regeneration and modulating the wound microenvironment.
  • Bioengineering Solutions: Engineering approaches to create functional skin constructs, including vascularized tissues and 3D bioprinted skin equivalents.
  • Management of Chronic Wounds: Innovative strategies specifically designed to address the challenges of diabetic ulcers, pressure ulcers, and venous leg ulcers, including infection control and biofilm disruption.

By bringing together a diverse collection of articles, this Special Issue aims to foster interdisciplinary collaboration and provide a comprehensive overview of the current state of the art and future directions in wound healing and repair. We look forward to receiving contributions that will help shape the next generation of therapies for patients suffering from acute and chronic wounds.

Dr. Wing Sum Siu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • wound care
  • tissue repair
  • bioactive dressings
  • skin regeneration
  • chronic wounds
  • regenerative medicine
  • stem cell therapy
  • biomaterials
  • hydrogels
  • wound dressings
  • scaffolds

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Related Special Issue

Published Papers (2 papers)

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Research

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16 pages, 946 KB  
Communication
Cell-Free Wharton’s Jelly-Derived MSC Secretome in a Polymeric Carrier for Refractory Chronic Wounds: Two Cases
by John A. Dangerfield, Arkar W. Maung and Poovasit Klinoubol
Bioengineering 2026, 13(9), 1077; https://doi.org/10.3390/bioengineering13091077 - 16 Sep 2026
Abstract
Background: Chronic wounds that fail to heal despite debridement and advanced care are an unmet clinical need, particularly in elderly patients and those with peripheral arterial disease, for whom the alternatives are often indefinite maintenance or amputation. The mesenchymal stromal cell (MSC) secretome [...] Read more.
Background: Chronic wounds that fail to heal despite debridement and advanced care are an unmet clinical need, particularly in elderly patients and those with peripheral arterial disease, for whom the alternatives are often indefinite maintenance or amputation. The mesenchymal stromal cell (MSC) secretome is pro-reparative in preclinical models, but human evidence is concentrated on shorter-duration diabetic foot ulcers and has usually reported area reduction rather than complete closure. Methods: We describe two patients with long-standing, treatment-refractory wounds treated with a cell-free Wharton’s jelly-derived MSC secretome delivered in a thermoresponsive polymeric carrier that gels at the wound bed, applied every three days alongside standard care. Results: The cases comprise the following: Case 1, a 95-year-old woman with peripheral arterial disease and a two-year ankle ulcer refractory to multiple advanced products; and Case 2, a 69-year-old man with a one-year neuro-ischemic diabetic foot ulcer persisting after amputation and repeated debridement. Both achieved complete closure at approximately 27 and 28 weeks, respectively, from baseline wound areas of approximately 7.5 cm2 (Case 1) and 12 cm2 (Case 2), using approximately 20 mL of preparation each. Closure was sustained at the latest follow-up (27 March 2026, Case 1; 21 June 2026, Case 2). Treatment was well tolerated; Case 2 had an intercurrent infection requiring a brief pause. Conclusions: A two-patient series cannot establish efficacy, but complete closure in wounds this refractory supports controlled evaluation of this cell-free platform, with complete closure as the primary endpoint. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair, 2nd Edition)
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Review

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46 pages, 4815 KB  
Review
Sprayable Hydrogel Dressings in Wound-Healing Applications
by Lei Nie, Yuanyuan Lu and Wei Guo
Bioengineering 2026, 13(6), 618; https://doi.org/10.3390/bioengineering13060618 - 25 May 2026
Cited by 2 | Viewed by 1952
Abstract
With an increased number of chronic wounds and accidents worldwide, the need for advanced wound care approaches has been urgent. In this regard, sprayable hydrogel dressings have emerged as an innovative biomaterial due to their unique rheological properties, minimally invasive operation capabilities, excellent [...] Read more.
With an increased number of chronic wounds and accidents worldwide, the need for advanced wound care approaches has been urgent. In this regard, sprayable hydrogel dressings have emerged as an innovative biomaterial due to their unique rheological properties, minimally invasive operation capabilities, excellent adaptability to irregular surfaces, and in situ rapid gelation. This review focused on elaborating the main materials used to construct sprayable hydrogels, including natural polymers and synthetic polymers, and discussing their respective molecular structures, physicochemical properties, advantages, and challenges in formulation design. This review also explored the properties of sprayable hydrogels, including sprayability, adhesion performance, mechanical strength, moisture absorption, breathability, biocompatibility, and degradability. The mechanisms of their controllable gelation through chemical crosslinking and physical crosslinking strategies were analyzed. Subsequently, the applications of sprayable hydrogels in wound areas, including diabetic wounds, infected wounds, postoperative adhesions, burn wounds, and joint wounds, were comprehensively reviewed. The challenges and future developments in wound healing were clarified to provide valuable references for promoting interdisciplinary research and the clinical translation of sprayable hydrogels. Full article
(This article belongs to the Special Issue Recent Advancements in Wound Healing and Repair, 2nd Edition)
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