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BioChem
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Feature Papers in BioChem
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Feature Papers in BioChem

A special issue of BioChem (ISSN 2673-6411).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 5975

Special Issue Editors

Prof. Dr. Buyong Ma

E-Mail Website
Guest Editor
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China
Interests: computational chemistry and biology; computational immunology; protein-protein interaction; protein aggregation diseases; neurodegenerative disease; alzheimer’s disease; cancer and inflammation; antigen receptors and signaling; antibody design
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Manuel Aureliano

E-Mail Website
Guest Editor
Faculdade de Ciencias e Tecnologia, Universidade do Algarve, Faro, Algarve, Portugal
Interests: metals in biology; polyoxometalates in biomedical sciences; interactions of POMs with proteins; bioinorganic chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As the Associate Editor-in-Chief of the esteemed journal BioChem (ISSN 2673-6411), I am excited to announce the launch of an inaugural Special Issue titled “Feature Papers in BioChem, 1st Edition”. This Special Issue aims at showcasing exceptional research in the diverse and interconnected fields of molecular biology, cell biology, structural biology, nucleic acid biology, chemical biology, synthetic biology, disease biology, biophysics, metallomics (or inorganic biochemistry), and theoretical biochemistry. As an international and interdisciplinary open-access journal, BioChem is dedicated to providing a platform for publishing high-quality reviews, research articles, communications, and letters that contribute to the advancement of scientific knowledge.

At BioChem, our primary objective is to encourage scientists to present their experimental and theoretical research in meticulous detail. We believe that the comprehensive reporting of research methodologies, results, and interpretations is crucial for advancing scientific understanding and enabling reproducibility. By emphasizing the importance of detailed reporting, we aim at fostering a culture of transparency and open science within the scientific community.

To ensure the publication of exceptional research, all submitted papers will undergo a rigorous evaluation process. Our team of knowledgeable Editors will conduct an initial assessment to determine the suitability of the submissions for the Special Issue. Following this, the selected papers will be subjected to a thorough and unbiased peer review by experts in the respective fields. This rigorous peer review process aims at maintaining the highest standards of scientific integrity and ensuring that only significant and impactful research is published in BioChem.

By launching the “Feature Papers in BioChem, 1st Edition” Special Issue, we endeavor to provide a platform for researchers to disseminate their groundbreaking discoveries and innovative methodologies. This Special Issue will serve as a catalyst for scientific collaboration and knowledge exchange among experts from various disciplines. It will enable scientists to stay updated on the latest advancements in biochemistry and related fields while also inspiring future investigations.

As an international open-access journal, BioChem ensures that published research is freely accessible to a global audience. This accessibility facilitates widespread dissemination, allowing researchers, educators, students, and policymakers to benefit from the latest findings and advancements in biochemistry. Moreover, the journal's interdisciplinary nature promotes the cross-pollination of ideas and encourages the development of novel approaches and solutions to scientific challenges.

In conclusion, the “Feature Papers in BioChem, 1st Edition” Special Issue represents an exciting opportunity for researchers to contribute to the scientific literature in the fields of molecular biology, cell biology, structural biology, nucleic acid biology, chemical biology, synthetic biology, disease biology, biophysics, and theoretical biochemistry. By emphasizing comprehensive reporting and rigorous peer review, BioChem ensures the publication of impactful and high-quality research. We invite scientists from around the world to submit their work to this Special Issue and join us in advancing the frontiers of biochemistry and related disciplines.

Prof. Dr. Buyong Ma
Dr. Manuel Aureliano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. BioChem is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular biology
  • molecular basis of biological processes
  • structural biology
  • gene and protein structure and expression
  • folding of biomolecules
  • biochemistry
  • metallomics (or inorganic biochemistry) chemical biology
  • synthetic biology
  • protein biosynthesis
  • membrane function and post-translational modification
  • disease biology
  • drugs and pharmaceutics
  • cell biology
  • chemical, physical, mechanistic, and/or structural basis of biological or cell function
  • cells
  • nucleic acid biology
  • theoretical biochemistry
  • advances in biochemical, biophysical, and molecular methodologies as well as imaging techniques and data analysis

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

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10 pages, 1197 KiB  
Article
Anti-Müllerian Hormone Serum Levels as Biomarker of Ovarian Reserve in Adult Women with Juvenile Idiopathic Arthritis Treated with csDMARDs and/or bDMARDs: A Pilot Study
by Clara Di Mario, Maria Rita Gigante, Angelina Barini, Luca Petricca, Antonella Barini, Antonio Bianchi, Stefano Alivernini, Barbara Tolusso and Elisa Gremese
BioChem 2024, 4(4), 313-322; https://doi.org/10.3390/biochem4040016 - 18 Oct 2024
Viewed by 615
Abstract
Background/Objectives: Juvenile idiopathic arthritis (JIA) is a chronic childhood disease that often persists into the reproductive years. JIA may impact long-term fertility due to the prolonged exposure to immunosuppressive therapies. Methods: A total of 35 adult JIA female patients of childbearing age and [...] Read more.
Background/Objectives: Juvenile idiopathic arthritis (JIA) is a chronic childhood disease that often persists into the reproductive years. JIA may impact long-term fertility due to the prolonged exposure to immunosuppressive therapies. Methods: A total of 35 adult JIA female patients of childbearing age and 20 age-matched healthy controls were studied to test their anti-Müllerian hormone (AMH) serum levels as a biomarker of ovarian reserve. Demographic characteristics, disease duration, previous and current treatments, disease activity (DAS44), and a health assessment questionnaire (HAQ) were recorded. Results: JIA patients had a mean age of 22.3 ± 2.9 years, a disease duration of 12.3 ± 6.1 years, and a DAS44 of 1.24 ± 0.61. No differences were found in AMH serum levels between JIA and controls (5.78 ± 2.37 ng/mL vs. 6.60 ± 2.68 ng/mL, respectively; p = 0.17). Among the patients, 22 (62.9%) were receiving a stable dose of methotrexate (MTX) and 19 (54.3%) a dose of TNFα inhibitors. No difference in AMH serum levels was observed between JIA patients who were or were not exposed to MTX (p = 0.29) or to TNFα inhibitors (p = 0.50). Conclusions: Ovarian reserve as assessed by AMH serum levels appears to be comparable between those with JIA and age-matched controls and does not appear to be influenced by disease characteristics or prior/concomitant exposure to immunosuppressive drugs. Full article
(This article belongs to the Special Issue Feature Papers in BioChem)
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22 pages, 4239 KiB  
Article
Proteomic Blueprint of Atlantic Cod (Gadus morhua) Otoliths Revealing Environmental Stress Insights through Label-Free Quantitative Shotgun Proteomics
by Trevena N. Youssef, Sherri L. Christian, Rick Rideout, Aaron Adamack, Pierre Thibault, Eric Bonneil, Travis D. Fridgen and Joseph Banoub
BioChem 2024, 4(2), 144-165; https://doi.org/10.3390/biochem4020008 - 19 Jun 2024
Viewed by 1083
Abstract
Otoliths of the fish’s inner ear serve as a natural chronological recorder because of their continuous formation marked by daily, monthly, and annual increments. Despite their importance, the comprehensive protein content of otoliths remains not fully identified. Using the label-free shotgun proteomics method [...] Read more.
Otoliths of the fish’s inner ear serve as a natural chronological recorder because of their continuous formation marked by daily, monthly, and annual increments. Despite their importance, the comprehensive protein content of otoliths remains not fully identified. Using the label-free shotgun proteomics method with one-dimensional liquid chromatography coupled to electrospray ionization-orbitrap tandem mass spectrometry, we quantified a broad range of proteins, with individual otoliths containing between 1341 and 1839 proteins. The identified proteins could potentially serve as a blueprint for fish growth from embryo to adult. We quantified eleven heat-shock proteins (HSPs) in both sexes and several proteins impacted by endocrine disruptors, indicating the otolith’s capacity to reflect environmental stress, potentially linked to climate change effects and altering of hormonal and neuroendocrine functions. Our bioinformatic ontology analysis confirmed the presence of proteins critical for various biological processes, including structural and enzymatic proteins. Protein–protein interaction (PPI) mapping also identified key interactions between the identified proteins. These findings significantly advance our understanding of otolith proteomics, offering a solid foundation for future work. Most of the identified proteins deposited daily and influenced by the environment were not implicated in the biomineralization of otolith, raising the potential for the otolith proteome to recreate details of fish life history at previously unrealized levels. Full article
(This article belongs to the Special Issue Feature Papers in BioChem)
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Review

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27 pages, 2485 KiB  
Review
Biotechnological Advances in Vanillin Production: From Natural Vanilla to Metabolic Engineering Platforms
by Arnold William Tazon, Fatima Awwad, Fatma Meddeb-Mouelhi and Isabel Desgagné-Penix
BioChem 2024, 4(4), 323-349; https://doi.org/10.3390/biochem4040017 - 27 Nov 2024
Viewed by 968
Abstract
Vanillin, an aromatic aldehyde, is one of the most popular flavors worldwide, extensively used in the food, cosmetics, pharmaceutical, and agrochemical industries. Despite its widespread use, less than 1% of the total vanillin production is natural, with the majority being synthesized chemically. While [...] Read more.
Vanillin, an aromatic aldehyde, is one of the most popular flavors worldwide, extensively used in the food, cosmetics, pharmaceutical, and agrochemical industries. Despite its widespread use, less than 1% of the total vanillin production is natural, with the majority being synthesized chemically. While chemical synthesis can help to meet the growing demand for vanillin, a strong market trend has rapidly developed for products created from natural ingredients, including natural vanillin. Given the labor-intensive process of extracting vanillin from vanilla pods, there is a critical need for new metabolic engineering platforms to support the biotechnological production of nature-identical vanillin. This review highlights the significance of vanillin in various markets, its diverse applications, and the current state of bio-engineered production using both prokaryotic and eukaryotic biological systems. Although recent advancements have demonstrated successful vanillin production through biocatalytic approaches, our focus was to provide a current and innovative overview of vanillin bioengineering across various host systems with special consideration placed on microalgae, which are emerging as promising platforms for vanillin production through metabolic engineering. The use of these systems to support the biotechnological production of vanillin, while leveraging the photosynthetic capabilities of microalgae to capture CO2 and convert it into biomass, can significantly reduce the overall carbon footprint. Full article
(This article belongs to the Special Issue Feature Papers in BioChem)
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28 pages, 2505 KiB  
Review
Oxidative Stress-Induced Gastrointestinal Diseases: Biology and Nanomedicines—A Review
by Maryam Rezvani
BioChem 2024, 4(3), 189-216; https://doi.org/10.3390/biochem4030010 - 29 Jul 2024
Viewed by 1403
Abstract
Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies have emphasized the critical role of oxidative stress in the pathogenesis of the most common gastrointestinal diseases. To provide a comprehensive overview of gastrointestinal [...] Read more.
Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies have emphasized the critical role of oxidative stress in the pathogenesis of the most common gastrointestinal diseases. To provide a comprehensive overview of gastrointestinal diseases caused by oxidative stress, their biological aspects, molecular mechanisms and specific pathways, the results of the most recent published articles from the online databases were studied considering both the upper and lower parts of the digestive tract. The results revealed that although the oxidative stress in each part of the digestive system manifests itself in a specific way, all these diseases arise from the imbalance between the generation of the reactive intermediates (especially reactive oxygen species) and the antioxidant defense system. Annual incidence and mortality statistics of gastrointestinal diseases worldwide emphasize the urgent need to find an effective and non-invasive treatment method to overcome these life-threatening problems. Therefore, in the next step, a variety of nanomedicurfines developed to treat these diseases and their effect mechanisms were investigated precisely. Furthermore, the most important nanomedicines responsive to endogenous and exogenous stimuli were evaluated in detail. This review could pave the way to open a new horizon in effectively treating gastrointestinal diseases. Full article
(This article belongs to the Special Issue Feature Papers in BioChem)
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Other

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13 pages, 518 KiB  
Systematic Review
Appropriate Prescription of Non-Steroidal Anti-Inflammatory Drugs in Geriatric Patients—A Systematic Review
by Carolina Costa, Diana Soares, Ana Borges, Ana Gonçalves, José Paulo Andrade and Hugo Ribeiro
BioChem 2024, 4(4), 300-312; https://doi.org/10.3390/biochem4040015 - 11 Oct 2024
Viewed by 1115
Abstract
The elderly population is growing worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed, but their adverse events can pose significant risks. Different NSAID molecules can exhibit varying risk profiles. This study aims to evaluate the cardiovascular, gastrointestinal, and renal safety profiles of ibuprofen, [...] Read more.
The elderly population is growing worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed, but their adverse events can pose significant risks. Different NSAID molecules can exhibit varying risk profiles. This study aims to evaluate the cardiovascular, gastrointestinal, and renal safety profiles of ibuprofen, naproxen, acemetacin, diclofenac, celecoxib, and etoricoxib in elderly patients. A comprehensive literature search was conducted in PubMed and Cochrane Library. For the selection of articles, we used Medical Subject Headings (MeSH) terms “aged” sequentially and together with “ibuprofen”, “diclofenac”, “naproxen”, “acemetacin”, “celecoxib”, and “etoricoxib”. To assess the quality and interest of the articles, four independent reviewers screened titles and abstracts to identify potentially eligible studies. Strength of Recommendation Taxonomy (SORT) was used to rate the quality of individual studies and to establish recommendation strengths (RS). From 2086 articles identified, 39 studies met the inclusion criteria. Twenty studies analyzed cardiovascular safety, fourteen gastrointestinal safety, and four renal safety. When CV risk is the main concern celecoxib or naproxen are a good first choice (RS B). In high GI risk addition of PPI to naproxen or celecoxib use should be recommended (RS A). When renal function is on focus, celecoxib remains as first line of therapy (RS A). Diclofenac in the geriatric population should be avoided (RS B). Celecoxib is a good choice for elderly patients for whom it is difficult to direct pain treatment based on a single known risk factor (RS B). Full article
(This article belongs to the Special Issue Feature Papers in BioChem)
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