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Feature Review Papers in "Applied Dentistry and Oral Sciences" Section
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Feature Review Papers in "Applied Dentistry and Oral Sciences" Section

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (20 February 2025) | Viewed by 18531

Special Issue Editors

Prof. Dr. Gianrico Spagnuolo

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
Interests: oral medicine; dental materials; operative dentistry; oral health
Special Issues, Collections and Topics in MDPI journals
Dr. Anabela Baptista Paula

E-Mail Website
Guest Editor
1. Faculty of Medicine, Institute of Integrated Clinical Practice, University of Coimbra, 3000-075 Coimbra, Portugal
2. Laboratory of Evidence-Based and Precision Dentistry, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal
3. Faculty of Medicine, Genetics and Oncobiology (CIMAGO), Area of Environment, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal
4. Centre for Innovate Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal
5. Clinical Academic Center of Coimbra (CACC), University of Coimbra, 3000-548 Coimbra, Portugal
6. Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), Advanced Production and Intelligent Systems (ARISE), Polo III, University of Coimbra, 3030-788 Coimbra, Portugal
7. Avenida Bissaya Barreto, Blocos de Celas, 3000-075 Coimbra, Portugal
Interests: dentistry; development of animal models for dental diseases (pulp capping, surgical models, and gastric pathology); mechanical evaluation of composite resins; biomaterials (from molecular biology to cell biology); new approaches for dental pulp treatment (from drug development to in vivo experiments); research in medicine based on clinical practice evidence (systematic reviews, meta-analyses, and patient-reported outcomes)
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Valletta

E-Mail Website
Guest Editor
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
Interests: operative dentistry; pedodontics

Special Issue Information

Dear Colleagues,

The Special Issue “Feature Review Papers in Section Applied Dentistry” aims to attract comprehensive reviews from all over the world relating to dentistry and oral biology. (https://www.mdpi.com/journal/applsci/sections/Applied_Dentistry)

We invite authors to contribute high-quality reviews that will contribute to this area. Suggested topics related to this Special Issue include, but are not limited to, the following:

  • Clinical dentistry;
  • Operative dentistry;
  • Implantology;
  • Imaging in dentistry;
  • Digital dentistry;
  • Orthodontics;
  • Oral surgery;
  • Pedondontics;
  • Endodontics;
  • Prosthetics dentistry.

Prof. Dr. Gianrico Spagnuolo
Dr. Anabela Baptista Paula
Dr. Alessandra Valletta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Review

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18 pages, 2711 KiB  
Review
10 Years of Convergent Neck Implants: A Systematic Review of Clinical Outcomes, Initial Original Concepts, and Changes in Surgical and Prosthetic Protocols
by Fausto Zamparini, Andrea Spinelli, Maria Giovanna Gandolfi and Carlo Prati
Appl. Sci. 2024, 14(17), 7568; https://doi.org/10.3390/app14177568 - 27 Aug 2024
Cited by 1 | Viewed by 1893
Abstract
The study reviewed the state of the art of the clinical use of a convergent-neck-designed Prama implant. This implant was introduced approximately 10 years ago and was characterized by a specific and unique convergent neck with a microtextured surface (UTM surface) and Zirconium [...] Read more.
The study reviewed the state of the art of the clinical use of a convergent-neck-designed Prama implant. This implant was introduced approximately 10 years ago and was characterized by a specific and unique convergent neck with a microtextured surface (UTM surface) and Zirconium Titanium (ZirTi) implant body surface. The neck design was developed to adopt the biologically oriented preparation technique (BOPT). A critical analysis of the published clinical studies and an evaluation of the adopted clinical protocols were performed. A total of forty-six articles were eligible to be reviewed. Only sixteen clinical studies reported clinical outcomes on Prama implants, and nine of these were selected having the longest follow-up from different research groups. The clinical follow-up/duration of the studies ranged from 12 months to 6 years. The initially proposed protocols explored neck supracrestal–transmucosal placement and gained interest due to its minimally invasive concept and the ability to proceed without a pre-prosthesis second surgery. The following investigations dedicated attention to the subcrestal or equicrestal implant placement with the conventional flap approach. The clinical studies characterized by the transmucosal exposed neck approach reported high survival rates with a stable bone morphology and reduced bone loss during the follow-up. Further recent implementations included the introduction of different convergent neck heights that need to be evaluated. The use of intraoral scanner technologies and digital workflow resulted in a simpler methodology with control of the marginal crown morphology. The studies support the concept that the hard tissue parameters (such as marginal bone level, MBL) and soft tissue parameters (such as pink esthetic score, PES) were stable or improved during the follow-up. Definitive crowns, designed with low invasiveness for soft tissues, were possible thanks to the morphology of the neck. The clinical studies support the use of the Prama implant with the different neck positions, demonstrating hard tissue preservation and optimal esthetic results in the first years following insertion. However, the current body of evidence is not robust enough to draw definitive conclusions, especially in the long term, and further high-quality research (long-term randomized trials) is required to consolidate these early observations. Full article
(This article belongs to the Special Issue Feature Review Papers in "Applied Dentistry and Oral Sciences" Section)
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19 pages, 1834 KiB  
Review
Clinical Applications of Low-Intensity Pulsed Ultrasound and Its Underlying Mechanisms in Dentistry
by Yuzi Wei and Yongwen Guo
Appl. Sci. 2022, 12(23), 11898; https://doi.org/10.3390/app122311898 - 22 Nov 2022
Cited by 6 | Viewed by 6752
Abstract
Low-intensity pulsed ultrasound (LIPUS) serves as a non-invasive treatment tool that reaches the lesion site in the form of ultrasound. Due to its low toxicity, low thermal effect, and low immunogenicity, LIPUS has attracted wide interest in disease treatment. It has been demonstrated [...] Read more.
Low-intensity pulsed ultrasound (LIPUS) serves as a non-invasive treatment tool that reaches the lesion site in the form of ultrasound. Due to its low toxicity, low thermal effect, and low immunogenicity, LIPUS has attracted wide interest in disease treatment. It has been demonstrated that LIPUS can activate multiple signal pathways in the shape of sound wave and one of the most acknowledged downstream response components is integrin/focal adhesion kinase (FAK) complex. In recent years, the functions of LIPUS in bone regeneration, bone healing, bone mass maintenance, and cellular metabolism were found. Various oral diseases and their treatments mainly involve hard/soft tissue regeneration and reconstruction, including periodontitis, orthodontic tooth movement (OTM), dental implant, mandibular deficiency, and dentin-pulp complex injury. Thus, more and more researchers pay close attention to the application prospects of LIPUS in stomatology. We searched these articles in PubMed with keywords LIPUS, temporomandibular joint (TMJ), periodontitis, orthodontics, and pulp, then classified the retrieved literature in the past five years by disease type. In this review, the function effects and possible mechanisms of LIPUS in periodontal tissue regeneration, orthodontic treatment, implant osseointegration, TMJ bone formation/cartilage protection, and dentin-pulp complex repair after injury will be summarized. The challenges LIPUS faced and the research limitations of LIPUS will also be elucidated. Therefore, this paper intends to provide new insights into oral disease treatments, explore the optimal application specification of LIPUS, and probe the future research orientation and the prospect of LIPUS in the dental field. Full article
(This article belongs to the Special Issue Feature Review Papers in "Applied Dentistry and Oral Sciences" Section)
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Other

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26 pages, 1769 KiB  
Systematic Review
The Effects of the Addition of Strontium on the Biological Response to Calcium Phosphate Biomaterials: A Systematic Review
by Juliana Alves Côrtes, Jessica Dornelas, Fabiola Duarte, Michel Reis Messora, Carlos Fernando Mourão and Gutemberg Alves
Appl. Sci. 2024, 14(17), 7566; https://doi.org/10.3390/app14177566 - 27 Aug 2024
Cited by 5 | Viewed by 2210
Abstract
Strontium is known for enhancing bone metabolism, osteoblast proliferation, and tissue regeneration. This systematic review aimed to investigate the biological effects of strontium-doped calcium phosphate biomaterials for bone therapy. A literature search up to May 2024 across Web of Science, PubMed, and Scopus [...] Read more.
Strontium is known for enhancing bone metabolism, osteoblast proliferation, and tissue regeneration. This systematic review aimed to investigate the biological effects of strontium-doped calcium phosphate biomaterials for bone therapy. A literature search up to May 2024 across Web of Science, PubMed, and Scopus retrieved 759 entries, with 42 articles meeting the selection criteria. The studies provided data on material types, strontium incorporation and release, and in vivo and in vitro evidence. Strontium-doped calcium phosphate biomaterials were produced via chemical synthesis and deposited on various substrates, with characterization techniques confirming successful strontium incorporation. Appropriate concentrations of strontium were non-cytotoxic, stimulating cell proliferation, adhesion, and osteogenic factor production through key signaling pathways like Wnt/β-catenin, BMP-2, Runx2, and ERK. In vivo studies identified novel bone formation, angiogenesis, and inhibition of bone resorption. These findings support the safety and efficacy of strontium-doped calcium phosphates, although the optimal strontium concentration for desired effects is still undetermined. Future research should focus on optimizing strontium release kinetics and elucidating molecular mechanisms to enhance clinical applications of these biomaterials in bone tissue engineering. Full article
(This article belongs to the Special Issue Feature Review Papers in "Applied Dentistry and Oral Sciences" Section)
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18 pages, 2254 KiB  
Systematic Review
The Influence of Probiotics in Halitosis and Cariogenic Bacteria: A Systematic Review and Meta-Analysis
by Victoria Offenbächer, Roberto Lo Giudice, José Nart, Francisco Real-Voltas, María Arregui, Alice Rose Greethurst and Cosimo Galletti
Appl. Sci. 2024, 14(15), 6639; https://doi.org/10.3390/app14156639 - 30 Jul 2024
Cited by 1 | Viewed by 6248
Abstract
Background: The aim of this systematic review was to evaluate the therapeutic potential of probiotics in patients with halitosis and to assess whether probiotics can also be implemented as a preventative tool in oral health. Secondary objectives included the effect of probiotics on [...] Read more.
Background: The aim of this systematic review was to evaluate the therapeutic potential of probiotics in patients with halitosis and to assess whether probiotics can also be implemented as a preventative tool in oral health. Secondary objectives included the effect of probiotics on oral-health-related quality of life, as well as their safety. Materials and methods: An electronic literature search in Medline (PubMed), Scopus, Web of Science, and the Cochrane library was carried out for the identification and selection of relevant randomized controlled trials. Eligibility was based on inclusion criteria, which included RCTs published after 2013, and the outcome variables were volatile sulfur compound (VSC) levels, organoleptic scores, plaque, or saliva samples to assess cariogenic bacteria counts and/or pH levels. Results: Out of 192 identified records, 16 randomized controlled trials were included. Ten of those studied the effects of probiotics on halitosis and the other six analyzed the effect of probiotics on oral health parameters, such as cariogenic bacteria counts, pH levels, and salivary flow and quality. A total of 921 patients were evaluated. The risk of bias was assessed using the Cochrane risk-of-bias assessment tool version 2. Conclusions: Probiotics exhibit the potential for oral health management by reducing VSC levels, improving saliva quality, and enhancing oral-health-related quality of life. Combining probiotics with tongue scraping may sustain VSC reduction, while symbiotics show potential in reducing tongue coating. However, different bacterial strains have been used in the included studies; hence, the conclusions cannot be generalized, being one of the main limitations of this review. Future research should explore the probiotics’ potential to persist in the oral cavity post-treatment and employ standardized methodologies for conclusive efficacy assessment. Full article
(This article belongs to the Special Issue Feature Review Papers in "Applied Dentistry and Oral Sciences" Section)
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