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Digital Dental Technology in Orthodontics

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 1660

Special Issue Editor


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Guest Editor
Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Catania, Italy
Interests: digital dentistry; imaging; orthodontics; TMJ disorders; oral pathology; oral cancer; orofacial pain; craniofacial growth; oral health; general health; quality of life
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The landscape of modern dentistry is undergoing a profound transformation, driven by rapid advancements in digital technologies and intelligent systems. Among these, artificial intelligence (AI) and machine learning (ML) play a pivotal role in redefining diagnostic accuracy, clinical decision-making, treatment personalization, and workflow optimization.

From automating the analysis of complex radiographic data to predicting treatment outcomes based on large-scale clinical datasets, AI-powered tools have the potential to enable a more precise, efficient, and patient-centered approach to oral healthcare.

This Special Issue aims to gather high-quality contributions that explore the development, validation, and clinical integration of AI and ML, and related digital innovations in all fields of dentistry. We welcome original research articles, reviews and case reports that highlight innovative applications and address current challenges and limitations in the field. Contributions that bridge the gap between computational sciences and dental clinical practice are of higher priority. Topics of interest include, but are not limited to the following:

  • Deep learning and computer vision for dental imaging diagnostics
  • AI-driven predictive models for disease progression and treatment outcomes
  • Automated cephalometric analysis, segmentation, and landmark detection
  • Decision support systems in orthodontics, implantology, endodontics, and prosthodontics
  • Integration of AI in digital workflows: from intraoral scanning to CAD-CAM design
  • Natural language processing in dentistry
  • Clinical validation, reproducibility, and interpretability of AI models in dentistry
  • Ethical, legal, and regulatory considerations in the deployment of AI technologies in oral healthcare
  • Integration of AI in tele-dentistry and patient monitoring systems

Prof. Dr. Rosalia Maria Leonardi
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence
  • machine learning
  • digital dentistry innovation
  • computer-aided diagnosis
  • digital clinical workflow

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Published Papers (1 paper)

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Review

43 pages, 31600 KB  
Review
Interactive Holographic Reconstruction of Dental Structures: A Review and Preliminary Design of the HoloDent3D Concept
by Tomislav Galba, Časlav Livada and Alfonzo Baumgartner
Appl. Sci. 2026, 16(1), 433; https://doi.org/10.3390/app16010433 - 31 Dec 2025
Cited by 1 | Viewed by 1350
Abstract
Panoramic radiography remains a cornerstone diagnostic tool in dentistry; however, its two-dimensional nature limits the visualisation of complex maxillofacial anatomy. Three-dimensional reconstruction from single panoramic images addresses this limitation by computationally generating spatial representations without additional radiation exposure or expensive cone-beam computed tomography [...] Read more.
Panoramic radiography remains a cornerstone diagnostic tool in dentistry; however, its two-dimensional nature limits the visualisation of complex maxillofacial anatomy. Three-dimensional reconstruction from single panoramic images addresses this limitation by computationally generating spatial representations without additional radiation exposure or expensive cone-beam computed tomography (CBCT) scans. This systematic review and conceptual study traces the evolution of 3D reconstruction approaches, from classical geometric and statistical shape models to modern artificial intelligence-based methods, including convolutional neural networks, generative adversarial networks, and neural implicit fields such as Occudent and NeBLa. Deep learning frameworks demonstrate superior accuracy in reconstructing dental and jaw structures compared to traditional techniques. Building on these advancements, this paper proposes HoloDent3D, a theoretical framework that combines AI-driven panoramic reconstruction with real-time holographic visualisation. The system enables interactive, radiation-free volumetric inspection for diagnosis, treatment planning, and patient education. Despite significant progress, persistent challenges include limited paired 2D–3D datasets, generalisation across anatomical variability, and clinical validation. Continued integration of multimodal data fusion, temporal modelling, and holographic visualisation is expected to accelerate the clinical translation of AI-based 3D reconstruction systems in digital dentistry. Full article
(This article belongs to the Special Issue Digital Dental Technology in Orthodontics)
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