From Natural to Synthetic Small-Molecule Antioxidants: New Candidates in Drug Discovery—Second Edition

Dear Colleagues,

In view of the great response we received with the previous Special Issue, "From Nature to Synthetic Small Molecule Antioxidants: New Candidates in Drug Discovery", we decided to continue addressing this topic through a Second Edition.

Natural compounds are well known for their invaluable contribution to pharmacological research in several therapeutic areas. Over the years, natural product collections have offered a wide variety of pharmacophores. These have been exploited in drug discovery to provide new lead compounds that are able to tackle even the most difficult screened targets.

This Special Issue, entitled “From Natural to Synthetic Small-Molecule Antioxidants: New Candidates in Drug Discovery—Second Edition”, aims to welcome both original articles and extensive reviews related to natural products, their derivatives, and de novo designed compounds in drug discovery efforts. Oxidative-stress-related conditions, reactive oxygen species, oxidative damage, and inflammatory stimuli are topics of great interest for modern medicinal chemistry, and therefore, they will be welcome in this Special Issue. For publication, we will consider the following topics: the bioactivity of medicinal plant extracts, the development of natural-derived compounds, biological applications and synthetic strategies for natural metabolites and/or analogues, and the rational or computer-aided design and development of synthetic small-molecule derivatives with pharmacological interest. Furthermore, applications looking at different disorders, from cancers to infectious diseases, as well as cardiovascular, neurological, and other human conditions, will also be considered.

Dr. Gabriele Carullo
Dr. Roberta Ibba
Dr. Valeria Tudino
Dr. Maria Dichiara
Guest Editors

Manuscript Submission Information

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