Physiology and Pathophysiology of Oxygen Sensitivity
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (15 April 2021) | Viewed by 33331
Special Issue Editors
Interests: oxygen sensing; carotid body; chemoreception; signalling pathways; hypoxia; intermittent hypoxia; neurotransmitters; reactive oxygen species; endothelial dysfunction
Special Issues, Collections and Topics in MDPI journals
Interests: oxygen sensing; hypoxic pulmonary vasoconstriction; reactive oxygen species; hydrogen sulphide; pulmonary hypertension
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Oxygen is such an essential element for life that multiple mechanisms have evolved to maintain oxygen homeostasis, including the ability of cells to detect and adapt to decreases in arterial O2. In mammals, O2 sensing mechanisms in erythropoietin-producing cells, peripheral chemoreceptor cells (carotid and aortic bodies), pulmonary artery smooth muscle and endothelial cells, chromaffin cells, and some types of neurons are particularly important in maintaining homeostasis.
Although acute O2 sensing by the carotid body (CB) and pulmonary vasculature initiates responses which allow the body to maintain adequate levels of blood oxygenation in the face of systemic hypoxemia and alveolar hypoxia, respectively, during chronic or long-term intermittent hypoxia, these responses evolve to become maladaptive. Continued CB stimulation leads to metabolic and cardiorespiratory disorders such as hypertension and heart failure, and sustained lung hypoxia causes pulmonary hypertension. Although much remains to be discovered about the mechanisms causing both the initial adaptive and subsequent deleterious responses to hypoxia, there is evidence from many laboratories for an essential role of oxidative stress at both stages.
This Special Issue will include a selection of research papers and review articles related to O2 sensing and oxidative stress, physiological responses to acute or chronic hypoxia, and maladaptive responses to the hypoxic environment and their more recent translational implications. We are currently seeking to expand the content of the Issue and would welcome the submission of up-to-date review articles and experimental papers.
We dedicate this Special Issue to our colleagues who made important contributions to the field of chemoreception and particularly to our understanding of the CB and who have passed away in the last decade: Prof. Sukhamay Lahiri (2009), Prof. Constancio Gonzalez (2015), Prof. Machiko Shirahata (2016), and Prof. Chris Peers (2018). We may have lost them, but their legacy continues through the research of many scientific heirs, students, collaborators, and friends.
Prof. Dr. Asuncion Rocher
Dr. Philip I. Aaronson
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxygen sensing
- acute and chronic hypoxia
- chemoreception
- carotid body
- pulmonary artery smooth muscle cells
- pulmonary artery endothelial cells
- HIF-1
- oxidative stress
- chemosensory potentiation
- hypoxic pulmonary vasoconstriction
- pulmonary hypertension
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.