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Review

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Department of Physiology, Indiana University School of Medicine—South Bend, South Bend, IN 46617, USA
Academic Editor: Stanley Omaye
Antioxidants 2021, 10(11), 1650; https://doi.org/10.3390/antiox10111650
Received: 25 August 2021 / Revised: 8 October 2021 / Accepted: 13 October 2021 / Published: 21 October 2021
(This article belongs to the Special Issue Physiology and Pathophysiology of Oxygen Sensitivity)
The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O2 sensing mechanism. This hypothesis is based on observations that H2S and RSS metabolism is inversely correlated with O2 tension, exogenous H2S elicits physiological responses identical to those produced by hypoxia, factors that affect H2S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O2. H2S-mediated O2 sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O2 sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two. View Full-Text
Keywords: hypoxia; hypoxic vasoconstriction; hypoxic vasodilation; chemoreceptor; carotid body; chromaffin cell; evolution; mitochondria hypoxia; hypoxic vasoconstriction; hypoxic vasodilation; chemoreceptor; carotid body; chromaffin cell; evolution; mitochondria
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MDPI and ACS Style

Olson, K.R. A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism. Antioxidants 2021, 10, 1650. https://doi.org/10.3390/antiox10111650

AMA Style

Olson KR. A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism. Antioxidants. 2021; 10(11):1650. https://doi.org/10.3390/antiox10111650

Chicago/Turabian Style

Olson, Kenneth R. 2021. "A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism" Antioxidants 10, no. 11: 1650. https://doi.org/10.3390/antiox10111650

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