Effects of Phytochemical Antioxidants in the Treatment of Chronic Inflammation and Metabolic Diseases

Dear Colleagues,

Plant-derived phytochemicals act as antioxidants. Owing to the diversity of phytochemicals, they cover a wide spectrum of therapeutic indications against various oxidative stress-related diseases such as cancer, cardiovascular, autoimmune, and neurological diseases and have been a productive source of lead compounds for the development of novel medications. In particular, their structural diversity and multi-target activity make them highly attractive candidates for preventive and therapeutic applications. However, there are many difficulties with the existing research techniques used to study the various mechanisms of action of phytochemicals. Their pleiotropic and poly-pharmacological properties are often difficult and time-consuming to fully elucidate using conventional experimental approaches alone. Recently, there have been increasing efforts to understand the disease by integrating conventional molecular biological experiments, bio-big data analysis and AI technologies. Therefore, it is possible to develop a deeper understanding of the disease and the development of better treatments through a more integrated approach. Such integrative strategies can provide new insights into molecular targets, signaling pathways, and disease-associated biological networks. An important direction for future investigation is to further optimize integrated phytochemical analysis, using molecular biological, systems biological, and network pharmacological techniques to predict multiple targets. This Special Issue aims to identify molecular targets and the mechanisms of phytochemicals for oxidative stress-related diseases through a poly-pharmacological approach. It will also highlight interdisciplinary studies that support target prediction, mechanistic validation, and the discovery of more effective antioxidant-based therapeutic strategies.

Dr. Ki Sung Kang
Dr. Gabsik Yang
Dr. Young-Joo Kim
Guest Editors

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