Special Issue "Thioredoxin Family Proteins"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 28 February 2020.

Special Issue Editors

Guest Editor
Prof. Em. Junji Yodoi

Kyoto University, Inst. Virus Research, Kyoto, Japan
Japan Biostress Research Promotion Alliance (JBPA), Kyoto, Japan
Website | E-Mail
Interests: redox regulation; thioredoxin family; TXNIP/TBP2/VDUP1; stress signal; retrovirus; infection immunity; allergy
Guest Editor
Prof. Kiichi Hirota

Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University
Website | E-Mail
Interests: redox biology, transciption factors, TXNIP, inflammation, RNA-Seq, anesthesiology, bioinfomatics

Special Issue Information

Dear Colleagues,

The thioredoxin (Trx) system, comprising nicotinamide adenine dinucleotide phosphate, Trx reductase, and Trx, cooperating with TXNIP/TBP2/VDUP1, is critical for maintaining cellular redox balance and antioxidant function, including control of oxidative stress and cell death.

During the past few decades, it has been widely recognized that reduction–oxidation (redox) responses occurring at the intra- and extra-cellular levels are one of most important biological phenomena, and dysregulated redox responses are involved in the initiation and progression of multiple diseases.

We invite research and review papers in any area of the redox biology research field that are related, but not limited, to fundamental understanding of TRX and its family molecules, such as peroxiredoxin and gluraredoxin, and signaling pathways, diagnostic, prognostic, and pharmacogenomic biomarkers, molecular targets driving the regulation of human physiology and pathophysiology and clinical trial with new agents, and validation in animal models.

We hope that this Special Issue reflects the exciting era that we are living in with respect to the field of the TRX system and its applications in medicine and health science.

Prof. Em. Junji Yodoi
Prof. Kiichi Hirota
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Thioredoxin
  • thioredoxin reducatase
  • thioredoxin-interacting protein
  • glutaredoxin
  • peroxiredoxin
  • redoxisome
  • oxidative stress
  • inflammation
  • immunology
  • cancer
  • aging
  • diabetes mellitus

Published Papers

This special issue is now open for submission.
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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