Thiol, Redox Switch in Inflammation

Dear Colleagues,

Inflammation is a complex immune response that is initiated to protect the body from harmful stimuli such as pathogens, toxins, or injuries. However, when inflammation becomes chronic and dysregulated, it can lead to tissue damage, organ dysfunction, and the development of various diseases including rheumatoid arthritis, inflammatory bowel disease, neurodegenerative disorders, etc. Under chronic inflammatory conditions, sustained activation of redox-sensitive pathways can lead to a continuous production of pro-inflammatory mediators, perpetuating the inflammatory response.

Recently, thiol-dependent antioxidant systems, such as thioredoxin and glutathione/glutaredoxin systems, were found to act as a switch in chronic inflammation by modulating the redox state of proteins and enzymes involved in inflammatory signalling pathways. Therefore, therapeutic strategies that target thiol and redox regulation in chronic inflammation are being explored as potential treatments for inflammatory diseases.

This Special Issue would bring together research articles, reviews, and original studies that investigate the role of redox signalling and thiol compounds in the inflammatory process. The scope of the Special Issue could include, but is not limit, the following: immunity and infection; novel mechanisms by which thiol compounds and redox signalling pathways influence inflammation and contribute to the pathogenesis of chronic inflammatory conditions; the role of oxidative stress and redox imbalance in inflammatory responses; the identification of potential biomarkers of thiol-redox status in inflammation; the therapeutic potential of targeting thiol-redox pathways in inflammatory diseases; and so on.

Prof. Dr. Jun Lu
Dr. Jianqiang Xu
Prof. Dr. Martin E. Rottenberg
Guest Editors
Prof. Dr. Lili Zou
Guest Editor Assistant

Manuscript Submission Information

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• immunity
• infection
• chronic inflammation
• NLRP-3 inflammasome
• TXNIP
• nuclear factor kappa B (NF-κB)
• selenium
• sulphur
• thioredoxin
• reactive oxygen species
• redox signalling
• antioxidant