The Versatility of Mitochondrial Calcium: Insights in the Regulation of Redox Signaling

Dear Colleagues, 

This Special Issue will highlight studies relating to the interplay between calcium and redox signaling. Calcium (Ca²⁺) is a crucial second messenger involved in intracellular molecular routes, and it plays an essential role in cell fate decisions from birth, through to development, and finally to death. Ca²⁺ signaling is put in place by an intricate network of proteins, differently localized inside cells which sense and spread Ca²⁺ signals by spatio-temporal means in order to regulate cellular processes. Ca²⁺ signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Originally considered as simple detrimental by-products of metabolism, it is now evident that ROS generated in sub-toxic amounts may act as signaling molecules involved in various physio-pathological processes. This Special Issue aims to collect papers (both original articles and review) which highlight the crosstalk of these two systems in physiology, and how this can be dysregulated in human diseases generating potentially harmful effects.

Dr. Giampaolo Morciano
Guest Editor

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