Statins as Antioxidants: Beyond Their Cholesterol Lowering Activity
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 31 July 2025 | Viewed by 129
Special Issue Editors
2. Research Center of Health Education and Health Promotion, Università Politecnica delle Marche, 60100 Ancona, Italy
Interests: oxidative and nitrosative stress; bioactive compounds; NCDs; ageing; taste recognition
Special Issues, Collections and Topics in MDPI journals
Interests: ROS and RNS; taste recognition; exogenous antioxidants; enzymatic antioxidants; dysmetabolic diseases
Special Issue Information
Dear Colleagues,
Statins are traditionally known for their cholesterol-lowering effects, as they inhibit the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis. However, recently, statins have been studied for their additional benefits, particularly their potential antioxidant properties. While the antioxidant effects of statins represent an area of ongoing research, studies so far have shown that they can reduce markers of oxidative stress and improve endothelial function. In fact, statins may reduce oxidative stress by modulating various enzymes and pathways involved in the production of reactive oxygen species (ROS). This is significant because oxidative stress is a key player in the development of dysmetabolic diseases. Statins may also improve endothelial function, which is crucial to vascular health. They may reduce oxidative stress that damages blood vessel walls by promoting the availability of nitric oxide (NO), a molecule that helps dilate blood vessels. Statins have also been shown to inhibit NADPH oxidase, an enzyme implicated in ROS production. This may help protect against inflammation and vascular damage by reducing ROS levels. Last, but not least, statins are known to reduce inflammatory markers such as C-reactive protein (CRP), which may contribute to their antioxidant and anti-inflammatory effects. Since the results across different studies are inconclusive, for this Special Issue, we invite authors from any research field to submit their in-depth research (either research or review articles) to enhance our understanding and confirm the extent to which statins' antioxidant properties contribute to their overall benefits.
Dr. Arianna Vignini
Guest Editor
Dr. Sonila Alia
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- statins
- cholesterol
- HMGCoA reductase
- antioxidant
- anti-inflammatory
- dysmetabolic diseases
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