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Antioxidants
Special Issues
The Interaction of Redox Potential Modulators with Membrane Transporters
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The Interaction of Redox Potential Modulators with Membrane Transporters

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 July 2024) | Viewed by 9947

Special Issue Editor

Prof. Dr. Fátima Martel

E-Mail Website
Guest Editor
Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine of Porto, Porto, Portugal
Interests: transmembrane transport mechanisms; epithelial transport of organic compounds; plasma membrane transport of nutrients in cancer cells; modulation of membrane transport by xenobiotics; changes in membrane transport in pathological conditions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Membrane transport systems are essential components of cellular and body homeostasis, as they control the traffic of most biomolecules across membranes. They are fundamental to cellular processes, such as cell nutrition, ionic balance and metabolism, and at the organism level, they control nutrition, excretion, drug therapeutic effects and the toxicity of xenobiotics. Mutations in transport protein genes have been identified in the pathogenesis of a number of hereditary diseases, including cystic fibrosis, glucose/galactose malabsorption and Wilson's disease. Moreover, several human conditions are associated with functional changes in specific transporters. For instance, in cancer cells, changes in membrane transporters for important nutrients have been described.

The cellular redox potential interferes with membrane transport systems, but our knowledge about this is still very limited. In this context, several dietary compounds with antioxidant properties, such as polyphenolic compounds, present as interesting modulators of membrane transport activity with a potential beneficial effect on humans’ health.

In this Special Issue, the interaction between compounds able to interfere with the cellular or mitochondrial redox potentials and membrane transporters will be explored.

Potential topics include, but are not limited to, the following:

  • The effect of antioxidants or pro-oxidants on membrane transporters;
  • The mechanisms involved in the regulation of membrane transporters by the redox potential;
  • The effect of dietary compounds with antioxidant or pro-oxidant properties on membrane transport in cancer cells.

Prof. Dr. Fátima Martel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary compounds
  • membrane transport
  • pathologies
  • modulation

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Published Papers (4 papers)

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Research

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14 pages, 1564 KiB  
Article
A Prunus avium L. Infusion Inhibits Sugar Uptake and Counteracts Oxidative Stress-Induced Stimulation of Glucose Uptake by Intestinal Epithelial (Caco-2) Cells
by Juliana A. Barreto-Peixoto, Cláudia Silva, Anabela S. G. Costa, Gerardo Álvarez-Rivera, Alejandro Cifuentes, Elena Ibáñez, M. Beatriz P. P. Oliveira, Rita C. Alves, Fátima Martel and Nelson Andrade
Antioxidants 2024, 13(1), 59; https://doi.org/10.3390/antiox13010059 - 29 Dec 2023
Cited by 1 | Viewed by 2401
Abstract
Sweet cherry (Prunus avium L.) is among the most valued fruits due to its organoleptic properties and nutritional worth. Cherry stems are rich in bioactive compounds, known for their anti-inflammatory and antioxidant properties. Innumerable studies have indicated that some bioactive compounds can [...] Read more.
Sweet cherry (Prunus avium L.) is among the most valued fruits due to its organoleptic properties and nutritional worth. Cherry stems are rich in bioactive compounds, known for their anti-inflammatory and antioxidant properties. Innumerable studies have indicated that some bioactive compounds can modulate sugar absorption in the small intestine. In this study, the phenolic profile of a cherry stem infusion was investigated, as well as its capacity to modulate intestinal glucose and fructose transport in Caco-2 cells. Long-term (24 h) exposure to cherry stem infusion (25%, v/v) significantly reduced glucose (3H-DG) and fructose (14C-FRU) apical uptake, reduced the apical-to-basolateral Papp to 3H-DG, and decreased mRNA expression levels of the sugar transporters SGLT1, GLUT2 and GLUT5. Oxidative stress (induced by tert-butyl hydroperoxide) caused an increase in 3H-DG uptake, which was abolished by the cherry stem infusion. These findings suggest that cherry stem infusion can reduce the intestinal absorption of both glucose and fructose by decreasing the gene expression of their membrane transporters. Moreover, this infusion also appears to be able to counteract the stimulatory effect of oxidative stress upon glucose intestinal uptake. Therefore, it can be a potentially useful compound for controlling hyperglycemia, especially in the presence of increased intestinal oxidative stress levels. Full article
(This article belongs to the Special Issue The Interaction of Redox Potential Modulators with Membrane Transporters)
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Review

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16 pages, 1297 KiB  
Review
Interplay between the Redox System and Renal Tubular Transport
by Xiao-Lan Wang, Lianjian Li and Xianfang Meng
Antioxidants 2024, 13(10), 1156; https://doi.org/10.3390/antiox13101156 - 24 Sep 2024
Cited by 1 | Viewed by 1678
Abstract
The kidney plays a critical role in maintaining the homeostasis of body fluid by filtration of metabolic wastes and reabsorption of nutrients. Due to the overload, a vast of energy is required through aerobic metabolism, which inevitably leads to the generation of reactive [...] Read more.
The kidney plays a critical role in maintaining the homeostasis of body fluid by filtration of metabolic wastes and reabsorption of nutrients. Due to the overload, a vast of energy is required through aerobic metabolism, which inevitably leads to the generation of reactive oxygen species (ROS) in the kidney. Under unstressed conditions, ROS are counteracted by antioxidant systems and maintained at low levels, which are involved in signal transduction and physiological processes. Accumulating evidence indicates that the reduction–oxidation (redox) system interacts with renal tubular transport. Redox imbalance or dysfunction of tubular transport leads to renal disease. Here, we discuss the ROS and antioxidant systems in the kidney and outline the metabolic dysfunction that is a common feature of renal disease. Importantly, we describe the key molecules involved in renal tubular transport and their relationship to the redox system and, finally, summarize the impact of their dysregulation on the pathogenesis and progression of acute and chronic kidney disease. Full article
(This article belongs to the Special Issue The Interaction of Redox Potential Modulators with Membrane Transporters)
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17 pages, 1177 KiB  
Review
Mechanisms by Which Exogenous Substances Enhance Plant Salt Tolerance through the Modulation of Ion Membrane Transport and Reactive Oxygen Species Metabolism
by Shiqing Jiang, Zuwen Lan, Yinkang Zhang, Xinna Kang, Liran Zhao, Xiaolei Wu and Hongbo Gao
Antioxidants 2024, 13(9), 1050; https://doi.org/10.3390/antiox13091050 - 29 Aug 2024
Cited by 6 | Viewed by 1632
Abstract
Soil salinization is one of the major abiotic stresses affecting plant growth and development. Plant salt tolerance is controlled by complex metabolic pathways. Exploring effective methods and mechanisms to improve crop salt tolerance has been a key aspect of research on the utilization [...] Read more.
Soil salinization is one of the major abiotic stresses affecting plant growth and development. Plant salt tolerance is controlled by complex metabolic pathways. Exploring effective methods and mechanisms to improve crop salt tolerance has been a key aspect of research on the utilization of saline soil. Exogenous substances, such as plant hormones and signal transduction substances, can regulate ion transmembrane transport and eliminate reactive oxygen species (ROS) to reduce salt stress damage by activating various metabolic processes. In this review, we summarize the mechanisms by which exogenous substances regulate ion transmembrane transport and ROS metabolism to improve plant salt tolerance. The molecular and physiological relationships among exogenous substances in maintaining the ion balance and enhancing ROS clearance are examined, and trends and research directions for the application of exogenous substances for improving plant salt tolerance are proposed. Full article
(This article belongs to the Special Issue The Interaction of Redox Potential Modulators with Membrane Transporters)
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21 pages, 7207 KiB  
Review
Types of Membrane Transporters and the Mechanisms of Interaction between Them and Reactive Oxygen Species in Plants
by Ding Yuan, Xiaolei Wu, Xiangqun Jiang, Binbin Gong and Hongbo Gao
Antioxidants 2024, 13(2), 221; https://doi.org/10.3390/antiox13020221 - 9 Feb 2024
Cited by 8 | Viewed by 3538
Abstract
Membrane transporters are proteins that mediate the entry and exit of substances through the plasma membrane and organellar membranes and are capable of recognizing and binding to specific substances, thereby facilitating substance transport. Membrane transporters are divided into different types, e.g., ion transporters, [...] Read more.
Membrane transporters are proteins that mediate the entry and exit of substances through the plasma membrane and organellar membranes and are capable of recognizing and binding to specific substances, thereby facilitating substance transport. Membrane transporters are divided into different types, e.g., ion transporters, sugar transporters, amino acid transporters, and aquaporins, based on the substances they transport. These membrane transporters inhibit reactive oxygen species (ROS) generation through ion regulation, sugar and amino acid transport, hormone induction, and other mechanisms. They can also promote enzymatic and nonenzymatic reactions in plants, activate antioxidant enzyme activity, and promote ROS scavenging. Moreover, membrane transporters can transport plant growth regulators, solute proteins, redox potential regulators, and other substances involved in ROS metabolism through corresponding metabolic pathways, ultimately achieving ROS homeostasis in plants. In turn, ROS, as signaling molecules, can affect the activity of membrane transporters under abiotic stress through collaboration with ions and involvement in hormone metabolic pathways. The research described in this review provides a theoretical basis for improving plant stress resistance, promoting plant growth and development, and breeding high-quality plant varieties. Full article
(This article belongs to the Special Issue The Interaction of Redox Potential Modulators with Membrane Transporters)
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