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Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview

1
Pharma Nord (UK) Ltd., Telford Court, Morpeth, NE61 2DB Northumberland, UK
2
School of Pharmacy, Liverpool John Moores University, L3 5UA Liverpool, UK
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(2), 44; https://doi.org/10.3390/antiox8020044
Received: 9 January 2019 / Revised: 9 February 2019 / Accepted: 12 February 2019 / Published: 16 February 2019
(This article belongs to the Special Issue CoQ10 in Longevity)
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Abstract

Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Thus, randomised controlled clinical trials have shown supplementation with CoQ10 or CoQ10 plus selenium reduces mortality by approximately 50% in patients with cardiovascular disease, or in the normal elderly population, respectively. Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease. The beneficial role of supplemental CoQ10 in the above disorders is considered to result from a combination of its roles in cellular energy generation, as an antioxidant and as an anti-inflammatory agent. View Full-Text
Keywords: coenzyme Q10; oxidative stress; inflammation; diabetes; cardiovascular disease; chronic kidney disease and liver disease; mitochondria coenzyme Q10; oxidative stress; inflammation; diabetes; cardiovascular disease; chronic kidney disease and liver disease; mitochondria
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Mantle, D.; Hargreaves, I. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview. Antioxidants 2019, 8, 44.

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