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Antioxidants
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Antioxidants in Ferroptosis and Human Diseases
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Antioxidants in Ferroptosis and Human Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 7584

Special Issue Editor

Prof. Dr. Ester Tellone

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Interests: antioxidants; oxidative stress; red blood cells; oxygen; metabolic pathways; flavonoids; lipid peroxidation; hemoglobin; erythrocyte metabolism; blood; free radicals; free radical scavengers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue delves into the intricate interplay between antioxidants and ferroptosis, a recently discovered form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxides. Oxidative stress and lipid peroxidation are key drivers of various human diseases, including neurodegenerative disorders, cancer, and cardiovascular conditions. Antioxidants play a vital role in counteracting these processes by scavenging reactive oxygen species and protecting cells from damage. The emerging field of ferroptosis highlights the importance of maintaining a delicate balance between pro-oxidant and antioxidant systems.

Recent studies have demonstrated the potential of antioxidant interventions in preventing or alleviating ferroptosis-related pathologies. By inhibiting lipid peroxidation and modulating iron metabolism, antioxidants can mitigate ferroptosis-induced damage and preserve cellular homeostasis. This Special Issue aims to provide a comprehensive overview of the mechanisms underlying the involvement of antioxidants in ferroptosis and their impact on various human diseases. It explores the therapeutic potential of antioxidant-based strategies, including the use of natural compounds and synthetic molecules, in targeting ferroptosis and improving clinical outcomes.

The collection of articles in this Special Issue fosters a deeper understanding of the intricate relationship between antioxidants, ferroptosis, and human diseases, paving the way for novel therapeutic interventions and personalized treatment approaches.

Prof. Dr. Ester Tellone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ferroptosis
  • iron
  • lipid peroxidation
  • glutathione peroxidase
  • system Xc
  • human diseases
  • natural antioxidants
  • red blood cells
  • flavonoids
  • polyphenols

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Published Papers (2 papers)

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20 pages, 2840 KiB  
Article
Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies
by Parisa Faraji, Astrid Borchert, Shahin Ahmadian and Hartmut Kuhn
Antioxidants 2024, 13(2), 242; https://doi.org/10.3390/antiox13020242 - 17 Feb 2024
Cited by 8 | Viewed by 2868
Abstract
Ferroptosis is a special kind of programmed cell death that has been implicated in the pathogenesis of a large number of human diseases. It involves dysregulated intracellular iron metabolism and uncontrolled lipid peroxidation, which together initiate intracellular ferroptotic signalling pathways leading to cellular [...] Read more.
Ferroptosis is a special kind of programmed cell death that has been implicated in the pathogenesis of a large number of human diseases. It involves dysregulated intracellular iron metabolism and uncontrolled lipid peroxidation, which together initiate intracellular ferroptotic signalling pathways leading to cellular suicide. Pharmacological interference with ferroptotic signal transduction may prevent cell death, and thus patients suffering from ferroptosis-related diseases may benefit from such treatment. Butylated hydroxytoluene (BHT) is an effective anti-oxidant that is frequently used in oil chemistry and in cosmetics to prevent free-radical-mediated lipid peroxidation. Since it functions as a radical scavenger, it has previously been reported to interfere with ferroptotic signalling. Here, we show that BHT prevents RSL3- and ML162-induced ferroptotic cell death in cultured human neuroblastoma cells (SH-SY5Y) in a dose-dependent manner. It prevents the RSL3-induced oxidation of membrane lipids and normalises the RSL3-induced inhibition of the intracellular catalytic activity of glutathione peroxidase 4. The systemic application of BHT in a rat Alzheimer’s disease model prevented the upregulation of the expression of ferroptosis-related genes. Taken together, these data indicate that BHT interferes with ferroptotic signalling in cultured neuroblastoma cells and may prevent ferroptotic cell death in an animal Alzheimer’s disease model. Full article
(This article belongs to the Special Issue Antioxidants in Ferroptosis and Human Diseases)
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55 pages, 3745 KiB  
Systematic Review
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review
by Nemanja Živanović, Marija Lesjak, Nataša Simin and Surjit K. S. Srai
Antioxidants 2024, 13(3), 334; https://doi.org/10.3390/antiox13030334 - 10 Mar 2024
Cited by 6 | Viewed by 4142
Abstract
Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of [...] Read more.
Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease. Polyphenols, plant secondary metabolites known for many bioactivities, are being extensively researched in the context of their influence on ferroptosis which resulted in a great number of publications showing the need for a systematic review. In this review, an extensive literature search was performed. Databases (Scopus, Web of Science, PubMed, ScienceDirect, Springer) were searched in the time span from 2017 to November 2023, using the keyword “ferroptosis” alone and in combination with “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, and “chalcone”; after the selection of studies, we had 311 papers and 143 phenolic compounds. In total, 53 compounds showed the ability to induce ferroptosis, and 110 compounds were able to inhibit ferroptosis, and out of those compounds, 20 showed both abilities depending on the model system. The most researched compounds are shikonin, curcumin, quercetin, resveratrol, and baicalin. The most common modes of action are in the modulation of the Nrf2/GPX4 and Nrf2/HO-1 axis and the modulation of iron metabolism. Full article
(This article belongs to the Special Issue Antioxidants in Ferroptosis and Human Diseases)
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