Paraoxonase Modulation by Dietary Factors: Implications for Health and Disease

Dear Colleagues,

Human paraoxonase (PON) is a member of the gene family that includes paraoxonase 1 (PON1), PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert antioxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes that modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER)-stress-induced apoptosis. The pleiotropic roles exerted by PONs have been investigated in pathological conditions such as cardiovascular diseases, neurodegenerative diseases, inflammatory diseases, renal failure, and gastrointestinal disorders. PONs also provide microbial protection by hydrolyzing bacterial quorum lactone. There is increasing evidence that PONs may be involved in molecular mechanisms of cancer development and progression since alterations of PON expression and activity have been demonstrated in different human tumors. Due to the properties of PONs, it is of potential interest to identify environmental modulators of the activity and concentration of PONs. Dietary factors may represent one of the environmental factors potentially involved, and this Special Issue focuses on dietary factors that may affect the activity and concentration of PONs in humans.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning paraoxonases and the role that dietary factors can play in the modulation of PONs in both normal processes as well as diseased states.  

We look forward to your contribution.

Dr. Tiziana Bacchetti
Dr. Gianna Ferretti
Guest Editors

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