Bioactive Compounds: Antioxidant, Antibacterial, and Anti-Inflammatory Modulation—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2361

Special Issue Editors


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Guest Editor
Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380000, Chile
Interests: natural products; bioactive compounds; secondary metabolites; phytochemistry; medicinal plants; bee products; phenolic compounds; antioxidants; bioaccessibility
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
Interests: bioactive compounds; organic synthesis; medicinal chemistry; neurodegeneration; anti-cancer compounds; nuclear magnetic resonance; natural products; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive compounds derived from natural sources continue to attract significant scientific attention due to their multifaceted biological properties and potential applications in health and disease prevention. Among them, phenolic acids, flavonoids, terpenes, alkaloids, peptides, fatty acids, and other secondary metabolites exhibit potent antioxidant activities that play a fundamental role in mitigating oxidative stress—an underlying factor in inflammation, infection, and chronic degenerative disorders. Their chemical structures enable them to scavenge free radicals, neutralize reactive oxygen and nitrogen species, and chelate transition metals, thereby preserving cellular homeostasis.

Emerging evidence also highlights the complex interplay between oxidative stress and inflammatory or antibacterial responses, demonstrating that modulation of redox balance can influence immune signaling pathways and microbial resistance mechanisms. Moreover, advances in analytical chemistry, biochemistry, and synthetic strategies are enabling the identification, isolation, and structural modification of these compounds, expanding their potential for pharmaceutical, nutraceutical, and functional food development.

This second edition aims to present cutting-edge research and comprehensive reviews addressing the antioxidant, antibacterial, and anti-inflammatory modulation exerted by bioactive compounds from natural, semi-synthetic, or synthetic sources inspired by nature. We particularly welcome studies focusing on mechanistic insights, innovative extraction or characterization approaches, and novel applications contributing to the understanding and valorization of bioactive compounds for health promotion.

Dr. Raquel Bridi
Dr. Christian Espinosa-Bustos
Guest Editors

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Keywords

  • bioactive compounds
  • antioxidants
  • anti-inflammatory activity
  • antibacterial properties
  • reactive oxygen species
  • oxidative stress
  • phytochemicals

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Published Papers (2 papers)

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Research

17 pages, 14638 KB  
Article
Astragaloside IV Alleviates Trueperella pyogenes-Induced Endometritis via the Nrf2/HO-1 Signaling Pathway
by Chunyang Gou, Hetian Mu, Yueting Wang, Yanan Liu, Ziqi Peng, Yun Li, Mingwei Xing and Maozhen Qi
Antioxidants 2026, 15(2), 271; https://doi.org/10.3390/antiox15020271 - 22 Feb 2026
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Abstract
The increasing antimicrobial resistance of T. pyogenes, one of the principal pathogens associated with endometritis, presents a formidable challenge in veterinary medicine. Astragaloside IV (AS-IV) is a triterpene saponin compound isolated from the traditional Chinese medicine Astragalus membranaceus. While recognized as the [...] Read more.
The increasing antimicrobial resistance of T. pyogenes, one of the principal pathogens associated with endometritis, presents a formidable challenge in veterinary medicine. Astragaloside IV (AS-IV) is a triterpene saponin compound isolated from the traditional Chinese medicine Astragalus membranaceus. While recognized as the primary bioactive constituent of Astragalus membranaceus with diverse pharmacological properties, its potential to counteract T. pyogenes-induced endometritis has yet to be elucidated. In the current study, T. pyogenes infection models were successfully established in both mouse uteri and cultured goat endometrial epithelial cells (gEECs). Integrating histopathology, molecular biology and transcriptomic technology, this study characterized the multifaceted biological effects of AS-IV. Transcriptomic analysis indicates that the regulatory effects of AS-IV on T. pyogenes-induced infection are primarily associated with the enrichment of signaling pathways related to inflammation, apoptosis, and oxidative stress. Subsequent validation demonstrated that AS-IV treatment effectively alleviated T. pyogenes-induced endometrial damage by suppressing inflammation, apoptosis, and oxidative stress. These effects were mediated through Nrf2 and its downstream target HO-1, a mechanism further confirmed by the loss of protection upon Nrf2 inhibition. In summary, AS-IV protects the endometrium against T. pyogenes-induced inflammatory and oxidative damage by activating the Nrf2/HO-1 signaling pathway. Full article
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21 pages, 2513 KB  
Article
Experimental and In Silico Studies to Unravel the Antioxidant and Antibacterial Properties of Lichen Metabolites from Pseudocyphellaria compar and Pseudocyphellaria nudata
by Mauricio A. Cuellar, Jessica Mejía, Helena Quintero-Pertuz, Alejandro Castro-Álvarez, Marco Mellado, Waleska Vera-Quezada, Gloria Montenegro, Christian Espinosa-Bustos, Raquel Bridi and Cristian O. Salas
Antioxidants 2026, 15(1), 34; https://doi.org/10.3390/antiox15010034 - 25 Dec 2025
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Abstract
Lichens are a source of diverse compounds with a wide range of biological activities, making them of significant interest for novel drug development. In this study, metabolites were extracted from Lobariaceae lichens, and their antioxidant and antibacterial properties were experimentally investigated and explained [...] Read more.
Lichens are a source of diverse compounds with a wide range of biological activities, making them of significant interest for novel drug development. In this study, metabolites were extracted from Lobariaceae lichens, and their antioxidant and antibacterial properties were experimentally investigated and explained using various computational approaches. Specifically, four lichen metabolites were analyzed using three methods to assess their antioxidant capacity. Antibacterial activity assays were conducted against four pathogens, and the minimum inhibitory concentrations (MICs) of the most promising compounds were determined. Ab initio studies were performed to evaluate radical stability. A pharmacological target responsible for the antibacterial effect was identified, and possible binding sites and modes were studied in silico. Metabolite IX, physciosporin, exhibited the highest antioxidant activity, which was associated with the theoretical stability of the radical. Additionally, IX exhibited an MIC of 0.97 μg/mL against S. pyogenes, surpassing the potency of streptomycin. The RecA protein was identified as a potential target, and a possible binding site and pattern of interactions at that site were described. Finally, IX showed low cytotoxicity in human cancer cell lines and was predicted to have favorable oral absorption properties, supporting its potential as a promising antioxidant and antibacterial agent against S. pyogenes. Full article
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