Antioxidant Delivery Strategies for Prevention and Treatment of Skin Pathologies

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1411

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Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy
Interests: nanotechnology; lipid-based drug delivery systems; natural antioxidants; transdermal delivery systems; semisolid formulations
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Special Issue Information

Dear Colleagues,

The skin is the most external organ of the human body, representing a barrier, which protects the body from external effectors and toxicant agents. Furthermore, the skin is exposed to many drawbacks and risks, deriving, for instance, from exogenous and endogenous agents that can lead to oxidative stress and inflammatory diseases. The disorders and pathologies affecting the skin span from chronic, inflammatory skin diseases, such as atopic dermatitis and psoriasis, to cancers, such as melanoma. Research efforts are devoted to finding efficacious prevention strategies and therapies for skin diseases, such as evaluating plant-derived antioxidant agents, as well as novel drug delivery systems which are suitable for topical administration. Several approaches based on conventional or more specialized pharmaceutical formulations are under investigation, such as nanoplatforms aimed at promoting transdermal antioxidant delivery via the stratum corneum barrier.

This Special Issue welcomes the most recent innovations, as well updates regarding the potential of antioxidant delivery systems for dermatological applications.

Dr. Elisabetta Esposito
Guest Editor

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Keywords

  • drug delivery systems
  • skin delivery
  • antioxidant actives
  • skin pathologies

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Published Papers (1 paper)

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Research

21 pages, 5604 KiB  
Article
Gossypin-Loaded Ethosome Gel for Cutaneous Administration: A Preliminary Study on Melanoma Cells
by Agnese Bondi, Walter Pula, Mascia Benedusi, Giulia Trinchera, Anna Baldisserotto, Stefano Manfredini, Maria Grazia Ortore, Alessia Pepe, Paolo Mariani, Marc C. A. Stuart, Giuseppe Valacchi and Elisabetta Esposito
Antioxidants 2025, 14(2), 186; https://doi.org/10.3390/antiox14020186 - 5 Feb 2025
Viewed by 860
Abstract
A preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin. This plant-derived compound possesses many pharmacological properties, including antitumoral potential. Ethosome dispersions were designed as transdermal delivery systems for gossypin, employing two different production procedures. The evaluation [...] Read more.
A preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin. This plant-derived compound possesses many pharmacological properties, including antitumoral potential. Ethosome dispersions were designed as transdermal delivery systems for gossypin, employing two different production procedures. The evaluation of vesicle size distribution by photon correlation spectroscopy, morphology by cryogenic transmission electron microscopy, and gossypin entrapment capacity, as well as in vitro release and permeation by vertical diffusion cells, enabled us to select a production strategy based on the injection of a phosphatidylcholine ethanolic solution in water. Indeed, vesicles prepared by this method were almost unilamellar and measured roughly 150 nm mean diameter while displaying an entrapment capacity higher than 94%. Moreover, vesicles prepared by the ethanol injection method enabled us to control gossypin release and to improve its permeation with respect to the solution of the drug. To obtain semi-solid forms suitable for cutaneous gossypin administration, ethosome dispersions were thickened with 0.5% w/w xanthan gum, selected by a spreadability test. These ethosome gels were then further characterized by small- and wide-angle X-ray scattering, while their antioxidant activity was demonstrated in vitro by a radical scavenging assay. Finally, in vitro biological studies were conducted on A375 melanoma cell lines. Namely, wound healing and cell migration assays confirmed the potential antitumoral effect of gossypin, especially when loaded in the selected ethosomal gel. The promising results suggest further investigation of the potential of gossypin-loaded ethosomal gel in the treatment of melanoma. Full article
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