Antibody-Based Therapeutics Against COVID-19

A special issue of Antibodies (ISSN 2073-4468).

Deadline for manuscript submissions: closed (20 September 2021) | Viewed by 4238

Special Issue Editor


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Guest Editor
Center for Antiviral Research, Wuhan Institute of Virology (WIV), Chinese Academy of Sciences, 262 Jinlong Street, Jiangxia, Wuhan 430207, China
Interests: phage display; yeast display; B cell immortalization; vaccine design by epitope analysis; Fc fragments
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Special Issue Information

Dear Colleagues,

An emerging coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes the disease known as COVID-19. To date, SARS-CoV-2 continues to rapidly spread globally and seriously threaten public health. Therapeutic antibodies are shown to be very effective in the treatment of various diseases, including viral infection and immune disorder. Clinical trials with antibody-based drugs for COVID-19 are being performed all over the world. Some of them are quite promising. For example, Bamlanivimab, a neutralizing antibody against SARS-CoV-2, was authorized by the FDA for the treatment of COVID-19 in high-risk patients on November 9, 2020. This Special Issue will collect the last progress on antibody-based therapeutics against COVID-19 from bench to bedside.

Prof. Dr. Rui Gong
Guest Editor

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Keywords

  • SARS-CoV-2
  • COVID-19
  • antibody
  • viral infection
  • immune disorder

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Published Papers (1 paper)

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Research

9 pages, 1482 KiB  
Communication
Immune Maturation Effects on Viral Neutralization and Avidity of Hyperimmunized Equine Anti-SARS-CoV-2 Sera
by Myriam Belén González Viacava, Augusto Varese, Ignacio Mazzitelli, Laura Lanari, Lucía Ávila, María Julia García Vampa, Jorge Geffner, Osvaldo Cascone, José Christian Dokmetjian, Adolfo Rafael de Roodt and Matías Fingermann
Antibodies 2022, 11(1), 3; https://doi.org/10.3390/antib11010003 - 2 Jan 2022
Cited by 2 | Viewed by 3429
Abstract
Mass-vaccination against COVID-19 is still a distant goal for most low-to-middle income countries. The experience gained through decades producing polyclonal immunotherapeutics (such as antivenoms) in many of those countries is being redirected to develop similar products able to neutralize SARS-CoV-2 infection. In this [...] Read more.
Mass-vaccination against COVID-19 is still a distant goal for most low-to-middle income countries. The experience gained through decades producing polyclonal immunotherapeutics (such as antivenoms) in many of those countries is being redirected to develop similar products able to neutralize SARS-CoV-2 infection. In this study we analyzed the biological activity (viral neutralization or NtAb) and immunochemical properties of hyperimmune horses’ sera (HHS) obtained during initial immunization (I) and posterior re-immunization (R) cycles using the RBD domain of the SARS-CoV-2 spike protein as antigen. HHS at the end of the R cycle showed higher NtAb titers when compared to those after the I cycle (35,585 vs. 7000 mean NtAb, respectively). Moreover, this increase paralleled an increase in avidity (95.2% to 65.2% mean avidity units, respectively). The results presented herein are relevant for manufacturers of these therapeutic tools against COVID-19. Full article
(This article belongs to the Special Issue Antibody-Based Therapeutics Against COVID-19)
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