Special Issue "Antibody-Based Diagnostics"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 April 2019)
Antibodies are an important and vital constituent of adaptive immunity, with the potential to recognize an essentially unlimited set of foreign molecules (antigens). Antibodies are rapidly made in response to infections and, therefore, they have immense diagnostic value. Moreover, since Abs undergo affinity maturation and class/isotype switching in the course of infections, the Ab distribution can be used to distinguish between acute and chronic infections.
Besides infections, many diseases are characterized by specific Ab productions. In autoimmune diseases, Abs recognizing autoantigens (autoantibodies) are found in varying frequencies and have immense diagnostic value, although their pathophysiological role is uncertain. In allergic diseases Abs (IgE) have both diagnostic value and are the direct cause of disease, for which reason IgE neutralizing therapies are very successful. Some malignant and more benign lymphoproliferative diseases are characterized by production of monoclonal Abs or Ab fragments (M components), which have immense diagnostic value. In rare cases, cancers may also give rise to production of autoantibodies, which can be used diagnostically.
Finally, due to their specificity and versatility, tailor-made Abs, mainly in the form of monoclonal Abs, can be used diagnostically for measurement of a wide range of analytes/targets, most often in the form of sandwich immunoassays, immunocytochemistry/immunohistochemistry and flow-based cell assays. Such assays are continuously being refined and combined with other techniques, e.g. mass spectrometry, PCR, etc., making Ab-based diagnostics the most important technique in many areas of bio-medicine.
This Special Issue on antibody-based diagnostics aims to describe current state-of-the-art techniques and applications, as well as newer and emerging uses of antibodies in diagnostics.
Prof. Gunnar Houen
Dr. Nicole Hartwig Trier
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Autoimmune diseases
- Monoclonal antibodies
- Peptide antibodies
- Lymphoproliferative diseases