The Role of Efflux Pump Inhibitor in Bacterial Multidrug Resistance

Dear Colleagues,

Efflux pumps are protein constituents of all bacterial plasma membranes, and can recognize and extrude toxic compounds to the environment. The over-expression of these pumps is one of the hallmarks of the frequent failure of antimicrobial chemotherapy. For this reason the inhibition of efflux pumps could be an effective strategy to overcome multidrug resistance. Efflux pump inhibitors (EPIs) alone or in combination could restore the sensitivity of resistant strains by increasing the intracellular concentration of antibiotics and decreasing the level of intrinsic resistance. Concerning the chemical nature of EPIs, there are compounds from natural (plant) sources, semi-synthetic derivatives of existing EPIs, and fully synthetic EPIs as well.

This Special Issue of Antibiotics invites both reviews and original articles that consider efflux pump inhibitors as challenging tools to overcome multidrug resistance in bacteria.

Dr. Gabriella Spengler
Guest Editor

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