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Antibiotics
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Multidrug-Resistant Bacteria in Animals
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Multidrug-Resistant Bacteria in Animals

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 20442

Special Issue Editor

Dr. Kazuki Harada

E-Mail Website
Guest Editor
Faculty of Agriculture, Tottori University, Tottori, Japan
Interests: companion animal; food-producing animals; antimicrobial treatment; antimicrobial resistance

Special Issue Information

Antimicrobial resistance in bacteria of animal-origin is a major global concern not only in the veterinary field but also in the public health sector. Notably, infections due to multidrug-resistant (MDR) bacteria, including extended-spectrum β-lactamase-producing bacteria and methicillin-resistant staphylococci, have increased in frequency among food-producing and companion animals in recent years. Therefore, the development of a strategy for dealing with MDR bacteria is an urgent issue in veterinary medicine. This Special Issue of Antibiotics seeks manuscript submissions that enhance our understanding on the control, diganosis, and treatment of MDR bacterial infections in animals.

Dr. Kazuki Harada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • companion animal
  • food-producing animals
  • multidrug resistance
  • antimicrobial treatment
  • infection control

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Published Papers (4 papers)

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Research

13 pages, 3967 KiB  
Article
Transmission of Similar Mcr-1 Carrying Plasmids among Different Escherichia coli Lineages Isolated from Livestock and the Farmer
by Joaquim Viñes, Anna Cuscó, Sebastian Napp, Julio Alvarez, Jose Luis Saez-Llorente, Montserrat Rosàs-Rodoreda, Olga Francino and Lourdes Migura-Garcia
Antibiotics 2021, 10(3), 313; https://doi.org/10.3390/antibiotics10030313 - 17 Mar 2021
Cited by 30 | Viewed by 5227
Abstract
Colistin use has mostly been stopped in human medicine, due to its toxicity. However, nowadays, it still is used as a last-resort antibiotic to treat hospital infections caused by multi-drug resistant Enterobacteriaceae. On the contrary, colistin has been used in veterinary medicine until [...] Read more.
Colistin use has mostly been stopped in human medicine, due to its toxicity. However, nowadays, it still is used as a last-resort antibiotic to treat hospital infections caused by multi-drug resistant Enterobacteriaceae. On the contrary, colistin has been used in veterinary medicine until recently. In this study, 210 fecal samples from pigs (n = 57), calves (n = 152), and the farmer (n = 1) were collected from a farm where E. coli harboring mcr-1–mcr-3 was previously detected. Samples were plated, and mcr-genes presence was confirmed by multiplex-PCR. Hybrid sequencing which determined the presence and location of mcr-1, other antibiotic resistance genes, and virulence factors. Eighteen colistin resistant isolates (13 from calves, four from pigs, and one from the farmer) contained mcr-1 associated with plasmids (IncX4, IncI2, and IncHI2), except for two that yielded mcr-1 in the chromosome. Similar plasmids were distributed in different E. coli lineages. Transmission of mcr-1 to the farmer most likely occurred by horizontal gene transfer from E. coli of calf origin, since plasmids were highly similar (99% coverage, 99.97% identity). Moreover, 33 virulence factors, including stx2 for Shiga toxin E. coli (STEC) were detected, highlighting the role of livestock as a reservoir of pathotypes with zoonotic potential. Full article
(This article belongs to the Special Issue Multidrug-Resistant Bacteria in Animals)
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13 pages, 1154 KiB  
Article
Virulence Determinants and Multidrug Resistance of Escherichia coli Isolated from Migratory Birds
by Md. Saiful Islam, Md. Mehedi Hasan Nayeem, Md. Abdus Sobur, Samina Ievy, Md. Amirul Islam, Saifur Rahman, Md. Abdul Kafi, Hossam M. Ashour and Md. Tanvir Rahman
Antibiotics 2021, 10(2), 190; https://doi.org/10.3390/antibiotics10020190 - 15 Feb 2021
Cited by 51 | Viewed by 5880
Abstract
Migratory birds are carriers of multidrug resistant pathogenic Escherichia coli. However, their roles in the dissemination of these resistant pathogens are still being neglected in Bangladesh. The present study was therefore carried out to detect multidrug resistant E. coli. In addition, [...] Read more.
Migratory birds are carriers of multidrug resistant pathogenic Escherichia coli. However, their roles in the dissemination of these resistant pathogens are still being neglected in Bangladesh. The present study was therefore carried out to detect multidrug resistant E. coli. In addition, these isolates were also screened for the presence of avian pathogenic E. coli (APEC)-associated virulence genes. A total of 66 fecal matter samples of migratory birds were screened. E. coli were isolated and identified by culturing and biochemical tests followed by polymerase chain reaction (PCR). APEC-associated virulence genes were detected by PCR. Disk diffusion assays were employed to investigate antibiogram profiles. Bivariate analysis was performed to assess correlations in resistance patterns between antimicrobials and to assess associations between virulence genes of E. coli. Among the 66 samples assessed by PCR, 55 (83.33%) were found positive for E. coli. Of these 55 isolates, the APEC-associated virulence gene fimC was detected in 67.27% of the isolates, which was significantly higher than in the cases of iucD (29.09%) and papC (5.45%) genes. In addition, three isolates were found positive for all three virulence genes, while 23 and 12 isolates were positive for one and two virulence genes respectively. In the bivariate analysis, significant associations were detected between fimC and iucD virulence genes. Using the antibiogram, all E. coli isolates were found to be multidrug resistant (MDR). The isolates exhibited 100% resistance against ampicillin and erythromycin in addition to varying percentages of resistance against streptomycin, tetracycline, ciprofloxacin, and chloramphenicol. Highly positive correlations between tetracycline and ciprofloxacin, chloramphenicol and ciprofloxacin, chloramphenicol and tetracycline were observed by bivariate analysis. To the best of our knowledge, this is the first study that reports APEC-associated virulence genes of MDR E. coli from migratory birds in Bangladesh. Results indicate that migratory birds are reservoirs of MDR E. coli isolates carrying APEC-associated virulence genes, which can seriously contribute to the development of human and animal diseases. Full article
(This article belongs to the Special Issue Multidrug-Resistant Bacteria in Animals)
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17 pages, 936 KiB  
Article
Prevalence of Vancomycin-Resistant Enterococcus (VRE) in Companion Animals: The First Meta-Analysis and Systematic Review
by Yusuf Wada, Ahmad Adebayo Irekeola, Engku Nur Syafirah E.A.R., Wardah Yusof, Lee Lih Huey, Suwaiba Ladan Muhammad, Azian Harun, Chan Yean Yean and Abdul Rahman Zaidah
Antibiotics 2021, 10(2), 138; https://doi.org/10.3390/antibiotics10020138 - 31 Jan 2021
Cited by 22 | Viewed by 4606
Abstract
Antimicrobial resistance in companion animals is a major public health concern worldwide due to the animals’ zoonotic potential and ability to act as a reservoir for resistant genes. We report on the first use of meta-analysis and a systematic review to analyze the [...] Read more.
Antimicrobial resistance in companion animals is a major public health concern worldwide due to the animals’ zoonotic potential and ability to act as a reservoir for resistant genes. We report on the first use of meta-analysis and a systematic review to analyze the prevalence of vancomycin-resistant Enterococcus (VRE) in companion animals. Databases such as MedLib, PubMed, Web of Science, Scopus, and Google Scholar were searched. The information was extracted by two independent reviewers and the results were reviewed by a third. Two reviewers independently assessed the study protocol using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and the study quality using the Joanna Briggs Institute (JBI) critical appraisal checklist for prevalence data. OpenMeta analyst and comprehensive meta-analysis (CMA) were used for the meta-analysis. The random effect model was used, and publication bias was assessed using the Eggers test and funnel plot. Between-study heterogeneity was assessed, and the sources were analyzed using the leave-one-out meta-analysis, subgroup analysis and meta-regression. Twenty-two studies met the eligibility criteria, but because some studies reported the prevalence of VRE in more than one companion animal, they were considered as individual studies, and 35 studies were therefore added to the final meta-analysis. Sampling period of the included studies was from 1995–2018. Of the 4288 isolates tested in the included studies, 1241 were VRE. The pooled prevalence of VRE in companion animals was estimated at 14.6% (95% CI; 8.7–23.5%; I2 = 97.10%; p < 0.001). Between-study variability was high (t2 = 2.859; heterogeneity I2 = 97.10% with heterogeneity chi-square (Q) = 1173.346, degrees of freedom (df) = 34, and p < 0.001). The funnel plot showed bias, which was confirmed by Eggers test (t-value = 3.97165; p = 0.00036), and estimates from the leave-one-out forest plot did not affect the pooled prevalence. Pooled prevalence of VRE in dogs and cats were 18.2% (CI = 9.4–32.5%) and 12.3%, CI = 3.8–33.1%), respectively. More studies were reported in Europe than in any other continent, with most studies using feces as the sample type and disc diffusion as the detection method. With the emergence of resistant strains, new antimicrobials are required in veterinary medicine. Full article
(This article belongs to the Special Issue Multidrug-Resistant Bacteria in Animals)
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16 pages, 3355 KiB  
Article
Antimicrobial Resistance Risk Assessment Models and Database System for Animal-Derived Pathogens
by Xinxing Li, Buwen Liang, Ding Xu, Congming Wu, Jianping Li and Yongjun Zheng
Antibiotics 2020, 9(11), 829; https://doi.org/10.3390/antibiotics9110829 - 19 Nov 2020
Cited by 7 | Viewed by 3512
Abstract
(1) Background: The high use of antibiotics has made the issue of antimicrobial resistance (AMR) increasingly serious, which poses a substantial threat to the health of animals and humans. However, there remains a certain gap in the AMR system and risk assessment models [...] Read more.
(1) Background: The high use of antibiotics has made the issue of antimicrobial resistance (AMR) increasingly serious, which poses a substantial threat to the health of animals and humans. However, there remains a certain gap in the AMR system and risk assessment models between China and the advanced world level. Therefore, this paper aims to provide advanced means for the monitoring of antibiotic use and AMR data, and take piglets as an example to evaluate the risk and highlight the seriousness of AMR in China. (2) Methods: Based on the principal component analysis method, a drug resistance index model of anti-E. coli drugs was established to evaluate the antibiotic risk status in China. Additionally, based on the second-order Monte Carlo methods, a disease risk assessment model for piglets was established to predict the probability of E. coli disease within 30 days of taking florfenicol. Finally, a browser/server architecture-based visualization database system for animal-derived pathogens was developed. (3) Results: The risk of E. coli in the main area was assessed and Hohhot was the highest risk area in China. Compared with the true disease risk probability of 4.1%, the result of the disease risk assessment model is 7.174%, and the absolute error was 3.074%. Conclusions: Taking E. coli as an example, this paper provides an innovative method for rapid and accurate risk assessment of drug resistance. Additionally, the established system and assessment models have potential value for the monitoring and evaluating AMR, highlight the seriousness of antimicrobial resistance, advocate the prudent use of antibiotics, and ensure the safety of animal-derived foods and human health. Full article
(This article belongs to the Special Issue Multidrug-Resistant Bacteria in Animals)
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