Special Issue "Veterinary and Comparative Reproductive Pathology"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Gabriele Marino
E-Mail Website
Guest Editor
Veterinary Science Department, University of Messina, Piazza Pugliatti, 1 - 98122 Messina, Italy
Interests: transmissible tumours; reproductive pathology; tumour-like lesions
Dr. Alessandra Sfacteria
E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy
Interests: mammary tumours; translational medicine; cytokines

Special Issue Information

Dear Colleagues,

Reproductive pathology is an interdisciplinary topic of the reproductive sciences. It is devoted to the understanding of the etiopathogenesis, morphology, and management of gynaecological and andrological diseases. The reproductive pathology of males focuses on the study of accessory glands, penis, and testis. Reproductive pathology of females includes the study of the cervix, uterine tube, ovary, uterus, vulva, vagina, and mammary gland. Genital organs modify continuously under hormonal control; the evaluation of pathological changes can be very challenging and implies a deep knowledge of the morphological and physiological changes during the reproductive cycles, such as the transition from puberty to adult age, from anoestrus to oestrus, and the changes of the uterus and mammary gland during pregnancy and puerperium. All kinds of approaches are welcome. Clinicopathological studies include the diagnostic procedures and the study of the biological characteristics of the disease. Classical gross and microscopic studies are powerful in helping to understand and classify the lesion in a comparative way. Molecular and genetic studies are ancillary investigations on pathologies able to support clinicians and pathologists in classification, staging, and treatment.

We invite original research papers, review articles, as well as short communications concerning infectious, degenerative, and proliferative lesions of the genital tract of wild and domestic animals. Additional topics about neonatal pathologies are welcome.

Dr. Gabriele Marino
Dr. Alessandra Sfacteria
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproduction
  • pathology
  • dysfunction
  • tumour
  • diagnostics
  • histology
  • immunohistochemistry
  • genetics

Published Papers (4 papers)

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Research

Article
Immune Cells and Immunoglobulin Expression in the Mammary Gland Tumors of Dog
Animals 2021, 11(5), 1189; https://doi.org/10.3390/ani11051189 - 21 Apr 2021
Viewed by 581
Abstract
Inflammatory cells have a role in tumor progression and have prognostic and therapeutic potential. The immunohistochemical expression for Mast Cell Tryptase, Macrophage Marker, CD79a, IgA, IgM and IgG on 43 cases of canine mammary gland lesions was analyzed. In hyperplasia, a few B [...] Read more.
Inflammatory cells have a role in tumor progression and have prognostic and therapeutic potential. The immunohistochemical expression for Mast Cell Tryptase, Macrophage Marker, CD79a, IgA, IgM and IgG on 43 cases of canine mammary gland lesions was analyzed. In hyperplasia, a few B cells (BCs) and Tumor-Associated Macrophages (TAMs) were observed, while the number of Tumor-Associated Mast Cells (TAMCs) was the highest. In the peritumoral stroma of malignant lesions, low number of TAMCs and a high number of TAMAs and BCs were present. Immune cells of each type were always lower in the intratumoral than peritumoral stroma. Positivity to CD79a was also detected in the epithelial cells of simple and micropapillay carcinomas. Immunoglobulin reactivity was mainly located in the epithelial cells where an intense positivity to IgA and IgG and a weak positivity for IgM were detectable. On the basis of our preliminary results and literature data, we suggest that such cells and molecules could be directly involved in the biology of canine mammary gland tumors. In breast cancer, stromal inflammatory cells and cancer derived immunoglobulins have been correlated with the progression, malignancy and poor prognosis of the tumor. The results herein reported show that the dog’s mammary gland epithelium also expresses immunoglobulins, and they mostly show a direct relationship with the infiltration of macrophages. In addition, this study shows that the infiltration of mast cells, B-cells and macrophages varies depending on the degree of malignancy of neoplasia. Full article
(This article belongs to the Special Issue Veterinary and Comparative Reproductive Pathology)
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Article
Use of Spinal Anaesthesia with Anaesthetic Block of Intercostal Nerves Compared to a Continuous Infusion of Sufentanyl to Improve Analgesia in Cats Undergoing Unilateral Mastectomy
Animals 2021, 11(3), 887; https://doi.org/10.3390/ani11030887 - 20 Mar 2021
Cited by 1 | Viewed by 468
Abstract
Unilateral mastectomy is a common surgical procedure in feline species and requires postoperative pain management. Our study aimed to evaluate the analgesic efficacy of subarachnoid anaesthesia combined with an intercostal nerve block, in comparison with the use of sufentanyl citrate administered as a [...] Read more.
Unilateral mastectomy is a common surgical procedure in feline species and requires postoperative pain management. Our study aimed to evaluate the analgesic efficacy of subarachnoid anaesthesia combined with an intercostal nerve block, in comparison with the use of sufentanyl citrate administered as a constant-rate infusion (CRI). Twenty cats were randomly divided into two groups (n = 10/group) based on the analgesic protocol used: the first received loco-regional anaesthesia with levobupivacaine (LR group), and the second received a CRI of sufentanyl (SUF group). The evaluation criteria during surgery were the need for a bolus of fentanyl in the event of an increased heart rate or increased blood pressure. In the postoperative period, the levels of comfort/discomfort and pain were used to obtain a score according to the UNESP-Botucatu multimodal scale. Subjects who scored above seven received analgesic drug supplementation. Intraoperative analgesia was satisfactory, with good haemodynamic stability in both groups. Four patients in the LR group required an extra dose of methadone after they achieved the sternal decubitus position, whereas those in the SUF group required many more doses. The analgesia achieved in the LR group was more satisfactory than that in the SUF group. Full article
(This article belongs to the Special Issue Veterinary and Comparative Reproductive Pathology)
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Article
Pseudo-Placentational Endometrial Hyperplasia in the Bitch: Case Series
Animals 2021, 11(3), 718; https://doi.org/10.3390/ani11030718 - 06 Mar 2021
Viewed by 513
Abstract
Canine pseudo-placentational endometrial hyperplasia differs from the classical form of cystic endometrial hyperplasia for the well-organized tissue architecture resembling the canine placenta. After the discovery, it has been inconstantly reported. The present work reports the clinicopathological details of six spontaneous cases retrieved retrospectively [...] Read more.
Canine pseudo-placentational endometrial hyperplasia differs from the classical form of cystic endometrial hyperplasia for the well-organized tissue architecture resembling the canine placenta. After the discovery, it has been inconstantly reported. The present work reports the clinicopathological details of six spontaneous cases retrieved retrospectively from a large database. The lesion was found in young non-pregnant female dogs (median 2.0 years) at the end of dioestrus. It could be imaged by ultrasound and was always grossly detectable as single or multiple uterine enlargements of 2–3 cm in diameter with a villous whitish tissue growing on the mucosa and occluding the lumen. Histology confirmed the tissue architecture of the canine placenta with a basal glandular layer, a connective band, a spongy layer and a tortuous and compact labyrinth, often poorly recognizable. The pseudo-placentational hyperplasia is a non-inflammatory proliferative lesion although numerous mast cells inhabit the connective band, and a superimposed inflammatory infiltrate was seen in a case. Canine pseudo-placentational endometrial hyperplasia has very peculiar features, and it is a model for canine placentation and may help to better understand the cystic endometrial hyperplasia/pyometra complex. Full article
(This article belongs to the Special Issue Veterinary and Comparative Reproductive Pathology)
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Article
Contrast-Enhanced Ultrasound Imaging of Prostate Gland in Neutered Dogs
Animals 2021, 11(2), 559; https://doi.org/10.3390/ani11020559 - 20 Feb 2021
Viewed by 640
Abstract
Prostatic neoplasia (PN) occurs in 5–7% of dogs with prostatic disease, with castrated dogs having the same or higher prevalence when compared to intact dogs. Considering the promising results achieved by performing contrast-enhanced ultrasound (CEUS) in intact dogs to detect PN, the present [...] Read more.
Prostatic neoplasia (PN) occurs in 5–7% of dogs with prostatic disease, with castrated dogs having the same or higher prevalence when compared to intact dogs. Considering the promising results achieved by performing contrast-enhanced ultrasound (CEUS) in intact dogs to detect PN, the present study aimed to acquire data on the prostatic perfusion pattern in neutered dogs. CEUS was performed in 64 neutered dogs, using a 5–7.5 MHz linear transducer with coded harmonic capability, dedicated analytical software, and a second-generation contrast agent, SonoVue. After B-mode evaluation was performed to assess mean prostate volume, the CEUS examination was undertaken. The flow of contrast agent was visible 10 s after injection. The subcapsular vessels were highlighted and produced rapid peripheral rim enhancement. Subsequently, the contrast agent reached the prostatic urethra via the parenchymal arterioles and gradually reached the entire prostate. Perfusion peak intensity (PPI) and time to peak (TTP) values were respectively 45.3% and 34.1 s. The measured parameters were compared with those obtained in previous studies on intact dogs with normal and with pathological patterns. In this study, CEUS showed features that may be promising for its use as a diagnostic tool for early detection of PN in neutered dogs. Full article
(This article belongs to the Special Issue Veterinary and Comparative Reproductive Pathology)
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