Special Issue "The Participation of Epithelial Cells in the Immune Response"

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Dr. Piotr Bąska
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Guest Editor
Institute of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, Ciszewskiego 8 Street, 02-786 Warsaw, Poland
Dr. Olga Witkowska - Piłaszewicz
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Co-Guest Editor
Institute of Veterinary Medicine, Department of Pathology and Veterinary Diagnostics, Nowoursynowska 159c Street, 02-776 Warsaw, Poland
Dr. Katarzyna Basałaj
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Co-Guest Editor
Witold Stefański Institute, PAS, Host Parasites Molecular Interactions Research Unit, Twarda 51/55 Street, 00-818 Warsaw, Poland

Special Issue Information

Dear colleagues,

     The role of epithelia in immune response is a significant and dynamically developing topic. Epithelial cells are the first line of innate immunity and release a number of agents regulating immune response. Their role in infectious diseases, allergies, and autoimmune diseases has been proven, mainly in human diseases and their animal models. In veterinary medicine, the topic remains less explored, encouraging further investigation. The aim of the Special Issue of Animals, titled "The Participation of Epithelial Cells in the Immune Response" is to collect, explore, and summarize the data regarding the topic. Review and experimental works concerning domestic and wild animals are both welcome. Data collected from the mouse models of human diseases may also be considered, but the impact of the research on animals needs to be proven. The main aims and scopes of the Issue are as follows:

 

  • Genomics, transcriptomics, and proteomics of epithelial cells
  • Interaction of epithelia with immune cells
  • Role of epithelial cells in immune response against infection agents
  • Interaction between epithelial cells and microbiota in sustaining welfare and maintaining animal health
  • Crosstalk of dietary ingredients and epithelia in sustaining the appropriate immune state of animals
  • Local immune response as a reaction for infection agents, injuries, and burns
  • Crosstalk between epithelia-induced immune response and hormone balance
  • Pathologies of epithelia and their impact on animal wellbeing.

Dr. Piotr Bąska
Dr. Katarzyna Basałaj
Dr. Olga Witkowska-Piłaszewicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune response
  • epithelial cells
  • animal diseases

Published Papers (1 paper)

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Research

Article
Induction of Serum Amyloid A3 in Mouse Mammary Epithelial Cells Stimulated with Lipopolysaccharide and Lipoteichoic Acid
Animals 2021, 11(6), 1548; https://doi.org/10.3390/ani11061548 - 25 May 2021
Viewed by 1270
Abstract
In this study, to establish whether serum amyloid A (SAA) 3 plays a role in the defense against bacterial infection in mouse mammary epithelium, normal murine mammary gland (NMuMG) epithelial cells were stimulated with lipopolysaccharide (LPS) and lipoteichoic acid (LTA). LPS and LTA [...] Read more.
In this study, to establish whether serum amyloid A (SAA) 3 plays a role in the defense against bacterial infection in mouse mammary epithelium, normal murine mammary gland (NMuMG) epithelial cells were stimulated with lipopolysaccharide (LPS) and lipoteichoic acid (LTA). LPS and LTA significantly enhanced mRNA expression level of the Saa3 gene, whereas no significant change was observed in the Saa1 mRNA level. Furthermore, LPS induced SAA3 protein expression more strongly than LTA, whereas neither LPS nor LTA significantly affected SAA1 protein expression. These data indicate that the expression of SAA3 in mouse mammary epithelial cells was increased by the stimulation with bacterial antigens. SAA3 has been reported to stimulate neutrophils in the intestinal epithelium and increase interleukin-22 expression, which induces activation of the innate immune system and production of antibacterial proteins, such as antimicrobial peptides. Therefore, collectively, these data suggest that SAA3 is involved in the defense against bacterial infection in mouse mammary epithelium. Full article
(This article belongs to the Special Issue The Participation of Epithelial Cells in the Immune Response)
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