Effects of Heat Stress on Animal Reproduction and Production

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal System and Management".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 456

Special Issue Editor


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Guest Editor
Instituto de Ciencias Agrícolas, Universidad Autónoma de Baja California, Mexicali 21705, Mexico
Interests: hot weather; hyperthermia; ruminants; mitigation measures; stress physiology

Special Issue Information

Dear Colleagues,

Heat stress involves undesirable effects on primary and functional traits in ruminants and, as a result, on the general productivity and profitability of these livestock systems. The increasing number of days with risky hot temperatures due to global warming suggests that it is vital to detect the heat stress status of animals based on adequate parameters, as well as to protect the animals, especially when they are raised and managed outdoors. This kind of thermal stress is associated with decreased feed intake, altered metabolism, compromised performance, impaired reproductive efficiency, and increased disease incidence. High metabolic heat production often requires robust thermoregulatory mechanisms to maintain body temperature inside the thermoneutral zone and thus the physiological homeostasis. Ruminants under intensive production systems are more sensitive to high environmental temperatures, so their easily undergo internal metabolism imbalance and inflammation, resulting in increased production and reproduction losses. The behavior of ruminants is also altered under heat stress conditions, which is a response intended to avoid the high heat loads that lead to hyperthermia.

This Special Issue looks at the main effects of heat stress on several productive and reproductive parameters in ruminants, as well as ways to mitigate them to avoid losses in terms of overall animal productivity.

Dr. Leonel Avendaño-Reyes
Guest Editor

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Keywords

  • hot environment
  • body temperature
  • milk production and composition
  • daily weight gain
  • growth rate
  • conception rate
  • reproductive efficiency
  • fertility
  • semen quality

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Published Papers (1 paper)

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Research

17 pages, 5739 KiB  
Article
Impact of Heat Stress on Gene Expression in the Hypothalamic–Pituitary–Ovarian Axis of Hu Sheep
by Jianwei Zou, Lili Wei, Yishan Liang, Juhong Zou, Pengfei Cheng, Zhihua Mo, Wenyue Sun, Yirong Wei, Jun Lu, Wenman Li, Yulong Shen, Xiaoyan Deng, Yanna Huang and Qinyang Jiang
Animals 2025, 15(15), 2189; https://doi.org/10.3390/ani15152189 - 25 Jul 2025
Viewed by 60
Abstract
Heat stress (HS) is a major environmental factor negatively impacting the reproductive performance of livestock. This study investigates the molecular mechanisms of heat stress on the hypothalamic–pituitary–ovarian (HPO) axis in Hu sheep. A heat-stressed animal model was established, and high-throughput RNA sequencing (RNA-seq) [...] Read more.
Heat stress (HS) is a major environmental factor negatively impacting the reproductive performance of livestock. This study investigates the molecular mechanisms of heat stress on the hypothalamic–pituitary–ovarian (HPO) axis in Hu sheep. A heat-stressed animal model was established, and high-throughput RNA sequencing (RNA-seq) was employed to analyze gene expression in the hypothalamus, pituitary, and ovarian tissues of both control and heat-stressed groups. The results revealed significant changes in estrus behavior, hormone secretion, and reproductive health in heat-stressed sheep, with a shortened estrus duration, prolonged estrous cycles, and decreased levels of FSH, LH, E2, and P4. A total of 520, 649, and 482 differentially expressed genes (DEGs) were identified in the hypothalamus, pituitary, and ovary, respectively. The DEGs were enriched in pathways related to hormone secretion, neurotransmission, cell proliferation, and immune response, with significant involvement of the p53 and cAMP signaling pathways. Tissue-specific responses to heat stress were observed, with distinct regulatory roles in each organ, including GPCR activity and cytokine signaling in the hypothalamus, calcium-regulated exocytosis in the pituitary, and cilium assembly and ATP binding in the ovary. Key genes such as SYN3, RPH3A, and IGFBP2 were identified as central to the coordinated regulation of the HPO axis. These findings provide new insights into the molecular basis of heat stress-induced impairments in reproductive function—manifested by altered estrous behavior, reduced hormone secretion (FSH, LH, E2, and P4), and disrupted gene expression in the hypothalamic–pituitary–ovarian (HPO) axis—and offer potential targets for improving heat tolerance and reproductive regulation in sheep. Full article
(This article belongs to the Special Issue Effects of Heat Stress on Animal Reproduction and Production)
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