Brain Sciences | Highly Cited Papers in 2022 and 2023 in the Section “Neurodegenerative Diseases”

Neurodegeneration holds profound modern significance as it represents a pressing challenge at the intersection of health, science, and society. With aging populations worldwide, the prevalence of neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS are steadily increasing, posing significant burdens on individuals, families, healthcare systems, and economies. Moreover, these conditions not only rob individuals of their cognitive and motor functions but also exact emotional, financial, and societal tolls. Understanding the underlying mechanisms of neurodegeneration has become a critical priority in biomedical research, not only to develop effective treatments but also to devise strategies for prevention and early intervention. Furthermore, as the quest for effective therapies intensifies, the study of neurodegeneration offers a gateway to unraveling the complexities of brain function and dysfunction, with potential implications extending beyond neurological disorders to broader questions about aging, cognition, and human resilience. Importantly, the “Neurodegenerative Diseases” Section of Brain Sciences (ISSN: 2076-3425) focuses on publishing articles covering a range of conditions including amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, prion diseases, and more.

All articles published in our journal are available in an open access format, granting you unrestricted access to the full free text. We invite you to explore our most highly cited papers from 2022 and 2023 listed below:

1. “Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease”
by Joshua N. Strelow, Till A. Dembek, Juan C. Baldermann, Pablo Andrade, Hannah Jergas, Veerle Visser-Vandewalle and Michael T. Barbe
Brain Sci. 2022, 12(12), 1726; https://doi.org/10.3390/brainsci12121726
Available online: https://www.mdpi.com/2076-3425/12/12/1726

2. “BDNF and Pro-BDNF in Amyotrophic Lateral Sclerosis: A New Perspective for Biomarkers of Neurodegeneration”
by Giulia Riolo, Claudia Ricci, Nicoletta De Angelis, Carlotta Marzocchi, Gisella Guerrera, Giovanna Borsellino, Fabio Giannini and Stefania Battistini
Brain Sci. 2022, 12(5), 617; https://doi.org/10.3390/brainsci12050617
Available online: https://www.mdpi.com/2076-3425/12/5/617

3. “Apathy in Parkinson’s Disease: Defining the Park Apathy Subtype”
by Ségolène De Waele, Patrick Cras and David Crosiers
Brain Sci. 2022, 12(7), 923; https://doi.org/10.3390/brainsci12070923
Available online: https://www.mdpi.com/2076-3425/12/7/923

4. “Capturing Subjective Mild Cognitive Decline in Parkinson’s Disease”
by Sara Rosenblum, Sonya Meyer, Ariella Richardson and Sharon Hassin-Baer
Brain Sci. 2022, 12(6), 741; https://doi.org/10.3390/brainsci12060741
Available online: https://www.mdpi.com/2076-3425/12/6/741

5. “The Role of Tryptophan Metabolism in Alzheimer’s Disease”
by Karl Savonije and Donald F. Weaver
Brain Sci. 2023, 13(2), 292; https://doi.org/10.3390/brainsci13020292
Available online: https://www.mdpi.com/2076-3425/13/2/292

6. “OViTAD: Optimized Vision Transformer to Predict Various Stages of Alzheimer’s Disease Using Resting-State fMRI and Structural MRI Data”
by Saman Sarraf, Arman Sarraf, Danielle D. DeSouza, John A. E. Anderson, Milton Kabia and The Alzheimer’s Disease Neuroimaging Initiative
Brain Sci. 2023, 13(2), 260; https://doi.org/10.3390/brainsci13020260
Available online: https://www.mdpi.com/2076-3425/13/2/260

7. “Exploring Whether Iron Sequestration within the CNS of Patients with Alzheimer’s Disease Causes a Functional Iron Deficiency That Advances Neurodegeneration”
by Steven M. LeVine, Sheila Tsau and Sumedha Gunewardena
Brain Sci. 2023, 13(3), 511; https://doi.org/10.3390/brainsci13030511
Available online: https://www.mdpi.com/2076-3425/13/3/511

8. “Visual Dysfunction in Parkinson’s Disease”
by Francisco Nieto-Escamez, Esteban Obrero-Gaitán and Irene Cortés-Pérez
Brain Sci. 2023, 13(8), 1173; https://doi.org/10.3390/brainsci13081173
Available online: https://www.mdpi.com/2076-3425/13/8/1173