Metabolism is one of the most important processes in the body. It enables the body to produce energy, but also to convert exogenous substances such as drugs into compounds that can be removed. A patient’s health status, polytherapy, and genetic factors have a significant impact on the rate of drug metabolism. This Section of Biomedicines (ISSN: 2227-9059) is organized into the following topics:

• Drug metabolism/biotransformation;
• Pharmacokinetics and pharmacodynamics;
• Toxicokinetics and toxicodynamics;
• Drug–drug interaction/drug–food interaction;
• Mechanism of drug absorption and disposition (including transporter);
• Drug delivery system;
• Factors affecting drug metabolism and transport;
• Expression of genes for drug-metabolizing enzymes and transporters;
• Pharmacogenetics and pharmacogenomics.

Read freely the following papers:

1. “Doppler Ultrasound Selection and Follow-Up of the Internal Mammary Artery as Coronary Graft”
by Pietro Scicchitano, Micaela De Palo, Giuseppe Parisi, Margherita Ilaria Gioia and Marco Matteo Ciccone
Biomedicines 2023, 11(1), 66; https://doi.org/10.3390/biomedicines11010066
Available online: https://www.mdpi.com/2227-9059/11/1/66

2. “Sex Differences in the Anti-Hypertensive Effect of Calcium-Channel Blockers: A Systematic Review and Meta-Analysis”
by Eveline M. van Luik, Esmée W. P. Vaes, Maud A. M. Vesseur, Nick Wilmes, Daniek A. M. Meijs, Sophie A. J. S. Laven, Zenab Mohseni-Alsalhi, Sander de Haas, Marc E. A. Spaanderman and Chahinda Ghossein-Doha
Biomedicines 2023, 11(6), 1622; https://doi.org/10.3390/biomedicines11061622
Available online: https://www.mdpi.com/2227-9059/11/6/1622

3. “Association between Antihyperlipidemic Agent Use and Age-Related Macular Degeneration in Patients with Hyperlipidemia: A Population-Based Retrospective Cohort Study”
by Chun-Hao Chen, Hsiu-Chen Lin, Hsiu-Li Lin, Joseph Jordan Keller and Li-Hsuan Wang
Biomedicines 2023, 11(6), 1508; https://doi.org/10.3390/biomedicines11061508
Available online: https://www.mdpi.com/2227-9059/11/6/1508

4. “Exploring Sex Differences of Beta-Blockers in the Treatment of Hypertension: A Systematic Review and Meta-Analysis”
by Nick Wilmes, Eveline M. van Luik, Esmée W. P. Vaes, Maud A. M. Vesseur, Sophie A. J. S. Laven, Zenab Mohseni-Alsalhi, Daniek A. M. Meijs, Cédric J. R. Dikovec, Sander de Haas, Marc E. A. Spaanderman et al.
Biomedicines 2023, 11(5), 1494; https://doi.org/10.3390/biomedicines11051494
Available online: https://www.mdpi.com/2227-9059/11/5/1494

5. “Pharmacokinetics of Biopharmaceuticals: Their Critical Role in Molecular Design”
by Takuo Ogihara, Kenta Mizoi and Akiko Ishii-Watabe
Biomedicines 2023, 11(5), 1456; https://doi.org/10.3390/biomedicines11051456
Available online: https://www.mdpi.com/2227-9059/11/5/1456

6. “The Representation of Females in Studies on Antihypertensive Medication over the Years: A Scoping Review”
by Zenab Mohseni-Alsalhi, Maud A. M. Vesseur, Nick Wilmes, Sophie A. J. S. Laven, Daniek A. M. Meijs, Eveline M. van Luik, Esmée W. P. Vaes, Cédric J. R. Dikovec, Jan Wiesenberg, Mohamad F. Almutairi et al.
Biomedicines 2023, 11(5), 1435; https://doi.org/10.3390/biomedicines11051435
Available online: https://www.mdpi.com/2227-9059/11/5/1435

7. “Effect of Low Protein Diet Supplemented with Ketoanalogs on Endothelial Function and Protein-Bound Uremic Toxins in Patients with Chronic Kidney Disease”
by George Chang, Hong-Mou Shih, Chi-Feng Pan, Chih-Jen Wu and Cheng-Jui Lin
Biomedicines 2023, 11(5), 1312; https://doi.org/10.3390/biomedicines11051312
Available online: https://www.mdpi.com/2227-9059/11/5/1312

8. “Reactive Oxygen Species Regulation of Chemoresistance and Metastatic Capacity of Melanoma: Role of the Cancer Stem Cell Marker CD271”
by Francesca Beretti, Martina Gatti, Manuela Zavatti, Sara Bassoli, Giovanni Pellacani and Tullia Maraldi
Biomedicines 2023, 11(4), 1229; https://doi.org/10.3390/biomedicines11041229
Available online: https://www.mdpi.com/2227-9059/11/4/1229

9. “Moderate-Intensity Exercise Improves Mesenteric Arterial Function in Male UC Davis Type-2 Diabetes Mellitus (UCD-T2DM) Rats: A Shift in the Relative Importance of Endothelium-Derived Relaxing Factors (EDRF)”
by Md Rahatullah Razan, Said Amissi, Rifat Ara Islam, James L. Graham, Kimber L. Stanhope, Peter J. Havel and Roshanak Rahimian
Biomedicines 2023, 11(4), 1129; https://doi.org/10.3390/biomedicines11041129
Available online: https://www.mdpi.com/2227-9059/11/4/1129

10. “Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role”
by Pietro Scicchitano, Massimo Iacoviello, Antonio Massari, Micaela De Palo, Angela Potenza, Raffaella Landriscina, Silvia Abruzzese, Maria Tangorra, Piero Guida, Marco Matteo Ciccone et al.
Biomedicines 2023, 11(3), 972; https://doi.org/10.3390/biomedicines11030972
Available online: https://www.mdpi.com/2227-9059/11/3/972

We would appreciate it if you would circulate the link of any of the papers you find appealing into your network. Furthermore, the following opportunities for collaboration may be of interest:

Submitting a manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link: https://susy.mdpi.com/user/manuscripts/upload/f17a01dbff7541081d1092edf09cd870?form%5Bjournal_id%5D=158.

Launching a Special Issue:
You have the opportunity to propose hot topics and edit a Special Issue together with experts in the field. Proposals may be submitted via the following link: https://www.mdpi.com/journalproposal/sendproposalspecialissue/biomedicines.

Joining the Editorial Board:
We are looking for active scholars who are interested in helping with the selection of submissions. Please do not hesitate to get in touch if you are interested in joining the Editorial Board (biomedicines@mdpi.com).

Biomedicines Editorial Office