Kidneys, like the “purification factory” of the body, filter waste and excess water from the blood. However, nowadays, the incidence of kidney disease is rising and it has become an invisible killer that poses a serious threat to health. We welcome you to read the following highly cited papers published in Journal of Clinical Medicine (JCM, ISSN: 2077-0383) , and hope that these articles can bring new ideas for kidney disease research. In addition, some Special Issues on this topic are currently open for submission.

1. “Pathomechanisms of Diabetic Kidney Disease”
by Satyesh K. Sinha and Susanne B. Nicholas
J. Clin. Med. 2023, 12(23), 7349; https://doi.org/10.3390/jcm12237349
Full text available online: https://www.mdpi.com/2077-0383/12/23/7349

2. “Renal Biopsy for Diagnosis in Kidney Disease: Indication, Technique, and Safety”
by Peter Schnuelle
J. Clin. Med. 2023, 12(19), 6424; https://doi.org/10.3390/jcm12196424
Full text available online: https://www.mdpi.com/2077-0383/12/19/6424

3. “Preventing Rejection of the Kidney Transplant”
by Divyanshu Malhotra and Priyanka Jethwani
J. Clin. Med. 2023, 12(18), 5938; https://doi.org/10.3390/jcm12185938 
Full text available online: https://www.mdpi.com/2077-0383/12/18/5938

4. “The Diagnostic and Prognostic Roles Played by Homocysteine and Other Aminothiols in Patients with Chronic Kidney Disease”
by Maria Petrovna Kruglova, Alexander Vladimirovich Ivanov, Anatolij Nikolaevich Fedoseev, Edward Danielevich Virus, Victor Aleksandrovich Stupin, Vladimir Anatolyevich Parfenov, Svetlana Andreevna Titova, Polina Igorevna Lazareva, Aslan Amirkhanovich Kubatiev and Ekaterina Vladimirovna Silina
J. Clin. Med. 2023, 12(17), 5653; https://doi.org/10.3390/jcm12175653
Full text available online: https://www.mdpi.com/2077-0383/12/17/5653

5. “Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review”
by Jun Kamei, Masafumi Kanamoto, Yutaka Igarashi, Kodai Suzuki, Kensuke Fujita, Tsukasa Kuwana, Takayuki Ogura, Katsunori Mochizuki, Yuki Banshotani, Hiroyasu Ishikura et al.
J. Clin. Med. 2023, 12(19), 6388; https://doi.org/10.3390/jcm12196388
Full text available online: https://www.mdpi.com/2077-0383/12/19/6388

6. “Sex-Related Aspects in Diabetic Kidney Disease—An Update”
by Ivonne Loeffler and Nadja Ziller
J. Clin. Med. 2023, 12(8), 2834; https://doi.org/10.3390/jcm12082834
Full text available online: https://www.mdpi.com/2077-0383/12/8/2834

7. “Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations”
by Christina Tamargo, Mohamad Hanouneh and C. Elena Cervantes
J. Clin. Med. 2024, 13(9), 2455; https://doi.org/10.3390/jcm13092455
Full text available online: https://www.mdpi.com/2077-0383/13/9/2455

8. “Chronic Kidney Disease in the Older Adult Patient with Diabetes”
by Raja Ravender, Maria-Eleni Roumelioti, Darren W. Schmidt, Mark L. Unruh and Christos Argyropoulos
J. Clin. Med. 2024, 13(2), 348; https://doi.org/10.3390/jcm13020348
Full text available online: https://www.mdpi.com/2077-0383/13/2/348

9. “Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts”
by Francesca Mallamaci and Giovanni Tripepi
J. Clin. Med. 2024, 13(3), 678; https://doi.org/10.3390/jcm13030678
Full text available online: https://www.mdpi.com/2077-0383/13/3/678

10. “Fibrosis in Chronic Kidney Disease: Pathophysiology and Therapeutic Targets”
by Allison B. Reiss, Berlin Jacob, Aarij Zubair, Ankita Srivastava, Maryann Johnson and Joshua De Leon
J. Clin. Med. 2024, 13(7), 1881; https://doi.org/10.3390/jcm13071881
Full text available online: https://www.mdpi.com/2077-0383/13/7/1881

11. “Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease”
by Didier Sánchez-Ospina, Sebastián Mas-Fontao, Carolina Gracia-Iguacel, Alejandro Avello, Marina González de Rivera, Maddalen Mujika-Marticorena and Emilio Gonzalez-Parra
J. Clin. Med. 2024, 13(5), 1428; https://doi.org/10.3390/jcm13051428
Full text available online: https://www.mdpi.com/2077-0383/13/5/1428

12. “Kidney Stones of Type I vs. Type II Diabetic Patients: Are There Any Differences?”
by Cătălin Pricop, Marius Ivănuță, Mihaela Nikolic and Dragoş Puia
J. Clin. Med. 2024, 13(20), 6110; https://doi.org/10.3390/jcm13206110
Full text available online: https://www.mdpi.com/2077-0383/13/20/6110

Special Issues:
“Challenges and Opportunities in Geriatric Nephrology and Urology” Guest Editor: Prof. Dr. Giulio Romano Submission deadline: 20 May 2025	“Kidney Transplantation: Current Challenges and Future Perspectives” Guest Editors: Dr. Alberto Piana and Dr. Angelo Territo Submission deadline: 20 May 2025
“Targeted Treatment of Kidney Stones” Guest Editors: Prof. Dr. Carmen Gonzalez-Enguita and Dr. Alberto Budía-Alba Submission deadline: 30 June 2025	“Acute Kidney Events in Intensive Care Patients” Guest Editor: Prof. Dr. Kada Klouche Submission deadline: 31 August 2025