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Volume 5
Issue 2
10.3390/rheumato5020007
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Case Report

Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins

by
Luis Angel Montero Furelos
1,*,
Clara Fernandez Peña
2 and
Beatriz San Millan Tejedor
3
1
Orthopedic Surgery and Traumatology Service, Hip Unit, Santiago de Compostela University Clinical Hospital, SERGAS, 15706 Santiago de Compostela, Spain
2
Department Internal Medicine, Santiago de Compostela University Clinical Hospital, SERGAS, 15706 Santiago de Compostela, Spain
3
Department Anatomo Pathology, Hospital Alvaro Cunqueiro, SERGAS, 36312 Vigo, Spain
*
Author to whom correspondence should be addressed.
Rheumato 2025, 5(2), 7; https://doi.org/10.3390/rheumato5020007
Submission received: 26 December 2024 / Revised: 14 May 2025 / Accepted: 29 May 2025 / Published: 19 June 2025
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Abstract

Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies. This condition may persist after statin discontinuation and requires immunosuppressive treatment. Despite these rare side effects, the benefits of statins outweigh the risks for most patients.
Keywords: immune-mediated necrotizing myopathy; statins; autoimmune myopathies immune-mediated necrotizing myopathy; statins; autoimmune myopathies

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MDPI and ACS Style

Montero Furelos, L.A.; Fernandez Peña, C.; San Millan Tejedor, B. Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins. Rheumato 2025, 5, 7. https://doi.org/10.3390/rheumato5020007

AMA Style

Montero Furelos LA, Fernandez Peña C, San Millan Tejedor B. Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins. Rheumato. 2025; 5(2):7. https://doi.org/10.3390/rheumato5020007

Chicago/Turabian Style

Montero Furelos, Luis Angel, Clara Fernandez Peña, and Beatriz San Millan Tejedor. 2025. "Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins" Rheumato 5, no. 2: 7. https://doi.org/10.3390/rheumato5020007

APA Style

Montero Furelos, L. A., Fernandez Peña, C., & San Millan Tejedor, B. (2025). Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins. Rheumato, 5(2), 7. https://doi.org/10.3390/rheumato5020007

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