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Medical Sciences Forum
Volume 3
Issue 1
10.3390/IECC2021-09215
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Proceeding Paper

The Electrochemical Behavior of Methotrexate upon Binding to the DNA of Different Cell Lines †

by
Douglas Vieira Thomaz
* and
Pierre Alexandre dos Santos
Faculty of Pharmacy, Federal University of Goiás, Goiânia 74690-900, GO, Brazil
*
Author to whom correspondence should be addressed.
†
Presented at the 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, 1–14 February 2021; Available online: https://iecc2021.sciforum.net/.
Med. Sci. Forum 2021, 3(1), 16; https://doi.org/10.3390/IECC2021-09215
Published: 29 January 2021
(This article belongs to the Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response)
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Abstract

Methotrexate (MTX) is a widely used anticancer agent whose DNA binding properties are well known. Despite its consolidated usage in the therapeutics of cancer, the physicochemical features of MTX binding to healthy and neoplastic DNA are still not fully understood. Therefore, this work showcases the electrochemical study of MTX binding to distinct DNA sequences through voltametric approaches.
Keywords: antineoplastic; diffusion coefficient; bioelectrochemistry; DNA; voltammetry antineoplastic; diffusion coefficient; bioelectrochemistry; DNA; voltammetry

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MDPI and ACS Style

Thomaz, D.V.; Santos, P.A.d. The Electrochemical Behavior of Methotrexate upon Binding to the DNA of Different Cell Lines. Med. Sci. Forum 2021, 3, 16. https://doi.org/10.3390/IECC2021-09215

AMA Style

Thomaz DV, Santos PAd. The Electrochemical Behavior of Methotrexate upon Binding to the DNA of Different Cell Lines. Medical Sciences Forum. 2021; 3(1):16. https://doi.org/10.3390/IECC2021-09215

Chicago/Turabian Style

Thomaz, Douglas Vieira, and Pierre Alexandre dos Santos. 2021. "The Electrochemical Behavior of Methotrexate upon Binding to the DNA of Different Cell Lines" Medical Sciences Forum 3, no. 1: 16. https://doi.org/10.3390/IECC2021-09215

APA Style

Thomaz, D. V., & Santos, P. A. d. (2021). The Electrochemical Behavior of Methotrexate upon Binding to the DNA of Different Cell Lines. Medical Sciences Forum, 3(1), 16. https://doi.org/10.3390/IECC2021-09215

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