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Future Pharmacology, Volume 2, Issue 1

March 2022 - 7 articles

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Articles (7)

  • Communication
  • Open Access
2,701 Views
7 Pages

Drug Repositioning in Intensive Care Patients and Pharmacokinetic Variability: The Illustration of Hydroxychloroquine

  • Gwendoline Ragonnet,
  • Elisabeth Jouve,
  • Lionel Velly,
  • Marc Leone,
  • Gary Duclos,
  • Jeremy Bourenne,
  • Karim Harti Souab,
  • Caroline Solas and
  • Romain Guilhaumou

During the SARS-CoV-2 pandemic, hydroxychloroquine (HCQ), was among the first drugs to be tested due to demonstrated in vitro antiviral activity against SARS-CoV-2. Pharmacokinetic variability was expected due to the frequent comorbidities and pathop...

  • Review
  • Open Access
18 Citations
7,850 Views
28 Pages

A Fresh Look on Bergenin: Vision of Its Novel Drug Delivery Systems and Pharmacological Activities

  • Sidharth Mehta,
  • Varsha Kadian,
  • Sweta Dalal,
  • Pooja Dalal,
  • Sunil Kumar,
  • Minakshi Garg and
  • Rekha Rao

Bergenin (BER), a key constituent of Bergenia crassifolia (Saxifragaceae), has gained extensive attention, owing to its array of pharmacological actions, including anti-infective, anti-cancer, anti-diabetic, neuroprotective, hepatoprotective, anti-ur...

  • Article
  • Open Access
2 Citations
3,920 Views
9 Pages

Multi-Donor Fecal Microbial Transplantation for Critically Ill Patients: Rationale and Standard Operating Procedure

  • Veronika Řehořová,
  • Ivana Cibulková,
  • Hana Soukupová and
  • František Duška

Patients in the intensive care unit often lose a considerable fraction of their gut microbiome due to exposure to broad-spectrum antibiotics and other reasons. Dysbiosis often results in prolonged diarrhea and increase occurrence of multi-drug resist...

  • Article
  • Open Access
16 Citations
3,948 Views
10 Pages

Increased Production of Taxoids in Suspension Cultures of Taxus globosa after Elicitation

  • Hebert Jair Barrales-Cureño,
  • Ana C. Ramos Valdivia and
  • Marcos Soto Hernández

The objectives of this study were to investigate whether elicitors induce the production of taxoids in Taxus globosa by testing the hypothesis that the cells induce a greater accumulation of taxoids depending on the type and concentration of the elic...

  • Article
  • Open Access
4 Citations
4,888 Views
14 Pages

Unraveling Drug Response from Pharmacogenomic Data to Advance Systems Pharmacology Decisions in Tumor Therapeutics

  • Konstantinos Kardamiliotis,
  • Evangelina Karanatsiou,
  • Ioanna Aslanidou,
  • Eirini Stergiou,
  • Ioannis S. Vizirianakis and
  • Andigoni Malousi

The availability of systematic drug response registries for hundreds cell lines, coupled with the comprehensive profiling of their genomes/transcriptomes enabled the development of computational methods that investigate the molecular basis of drug re...

  • Article
  • Open Access
3 Citations
3,738 Views
15 Pages

Antioxidant and Antifungal Activity of the Cynophalla flexuosa (L.) J. Presl (Capparaceae) against Opportunistic Fungal Pathogens

  • Gerson Javier Torres Salazar,
  • Joara Nalyda Pereira Carneiro,
  • Ana Cristina Albuquerque da Silva,
  • Beatriz Gonçalves Cruz,
  • Rakel Olinda Macedo da Silva,
  • José Galberto Martins da Costa,
  • Rafael Pereira da Cruz,
  • Josefa Carolaine Pereira da Silva,
  • Maciel Horácio Ferreira and
  • Antonia Thassya Lucas dos Santos
  • + 9 authors

The chemical composition of the Cynophalla flexuosa hydroethanolic extract (CFHEE) was identified and its antioxidant, antifungal and antipleomorphic activities against C. albicans and C. tropicalis strains were evaluated. Phytochemical prospecting e...

  • Review
  • Open Access
29 Citations
12,179 Views
15 Pages

Glycyrrhizic acid (GA) is the main active component of the licorice root, which has been known in traditional medicine since the ancient times. It is a molecule composed of a hydrophilic part, two glucuronic acid molecules, and a hydrophobic part, gl...

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Future Pharmacol. - ISSN 2673-9879Creative Common CC BY license