You are currently viewing a new version of our website. To view the old version click .

Compounds, Volume 5, Issue 3

September 2025 - 13 articles

Cover Story: Nowadays, treatments for early dementia and Alzheimer’s disease involve cholinesterase inhibition. Cannabis sativa L. is a therapeutic plant, used since ancient times, that produces poorly studied spermidine-type alkaloids. In this article, the alkaloids cannabisativine and anhydrocannabisativine were isolated from cannabis roots, demonstrating highly selective inhibition of butyrylcholinesterase. Combining bioguided isolation with advanced in silico modeling, the research highlights these compounds’ excellent binding affinity, selectivity, and promising low-toxicity profile. These findings open opportunities for drug discovery in neurodegenerative diseases while highlighting the sustainable use of cannabis agro-waste. This report will interest researchers in pharmacology, natural products, and sustainable chemistry. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (13)

  • Article
  • Open Access
875 Views
17 Pages

Support Surface Chemistry Evolution During the Preparation of Metal Oxide–Activated Carbon Catalysts by Wet Impregnation: A FT-IR Spectroscopy Analysis

  • Adrián Bogeat-Barroso,
  • María Francisca Alexandre-Franco,
  • Carmen Fernández-González and
  • Vicente Gómez Serrano

22 September 2025

The present work is aimed at shedding light on the evolution of surface chemistry of a commercial activated carbon (AC) support during the preparation of supported metal oxide (MO) catalysts by the conventional wet impregnation method. Particular att...

  • Article
  • Open Access
1 Citations
1,680 Views
15 Pages

Novel Butyrylcholinesterase Inhibitor Alkaloids from Cannabis sativa Roots: Bioguided Isolation and In Silico Study

  • Javier E. Ortiz,
  • Camila W. Adarvez-Feresin,
  • Olimpia Llalla-Cordova,
  • Diego Cristos,
  • Adriana Garro and
  • Gabriela E. Feresin

8 September 2025

Neurodegenerative diseases, including Alzheimer’s disease (AD), represent one of the main global health challenges. Cannabis sativa synthesizes spermidine-type alkaloids, whose potential biological activities have been little studied. This stud...

  • Article
  • Open Access
1 Citations
1,328 Views
20 Pages

Metal–Porphyrin-Based Covalent Organic Framework Composite Membrane for Salts and Dyes Separation

  • Fatimah Al-Ghazzawi,
  • Mohammed Mahdi Al-Mossawi and
  • Hadeel K. Allayeith

Covalent organic framework (COF) membranes are eminent candidates in filtration and separation applications due to their high porosity, ordered pore size, versatile molecular structure, inherent mechanical properties, and excellent stability. However...

  • Article
  • Open Access
765 Views
15 Pages

Heyang Fragrance, a traditional incense dating back to the Eastern Han Dynasty (25–220 AD), was recently inscribed on China’s national list of intangible cultural heritage. This study aimed to systematically analyze three variants of Heya...

  • Article
  • Open Access
1 Citations
1,149 Views
23 Pages

The advancement of catalytic materials is critical to improving the performance, reducing the cost and enhancing the sustainability of Proton Exchange Membrane (PEM) fuel cells and electrolyzers. Although Platinum Group Metal (PGM)-based electrocatal...

  • Article
  • Open Access
848 Views
15 Pages

Bioactive Properties and Fatty Acid Profile of Seed Oil from Amomyrtus luma

  • Claudia Giovagnoli-Vicuña,
  • Rafael Viteri,
  • Javiera Aparicio,
  • Issis Quispe-Fuentes and
  • Ady Giordano

Amomyrtus luma (A. luma), a native Chilean tree species, produces fruits containing 1–3 non-edible seeds, which are typically discarded as waste during processing. This study evaluated the fatty acid composition and bioactive properties of A. l...

  • Article
  • Open Access
1 Citations
634 Views
12 Pages

In Vitro Schistosomicidal Activity and Molecular Modeling of Quercitrin and Afzelin Isolated from the Leaves of Copaifera oblongifolia

  • Rafael Corrêa Ramos,
  • Lizandra G. Magalhães,
  • Rodrigo C. S. Veneziani,
  • Sérgio R. Ambrósio,
  • Renato Pereira Orenha,
  • Renato Luis Tame Parreira,
  • Márcio L. Andrade e Silva,
  • Jairo K. Bastos,
  • Murilo de Oliveira Souza and
  • Híllary Ozorio Gobeti Caprini
  • + 4 authors

Neglected diseases significantly impact the world, and there is a lack of effective treatments, requiring therapeutic alternatives. Thus, the study of the phytochemical and schistosomicidal activity evaluation of Copaifera oblongifolia leaves’...

  • Review
  • Open Access
4 Citations
2,833 Views
30 Pages

Emerging Technologies for Extracting Antioxidant Compounds from Edible and Medicinal Mushrooms: An Efficient and Sustainable Approach

  • Salome Mamani Parí,
  • Erick Saldaña,
  • Juan D. Rios-Mera,
  • María Fernanda Quispe Angulo and
  • Nils Leander Huaman-Castilla

Edible mushrooms are well-known for their culinary and nutritional values. Additionally, they serve as a natural source of polyphenols, a group of bioactive compounds that significantly treat diseases associated with oxidative stress. The polyphenoli...

  • Article
  • Open Access
1,073 Views
13 Pages

On the Computational Determination of the pKa of Some Arylboronic Acids

  • André Gustavo Horta Barbosa,
  • João Guilherme Siqueira Monteiro,
  • Noemi de Jesus Hiller and
  • Daniela de Luna Martins

An important property of arylboronic acids, particularly when considering their use in medicinal chemistry, is their pKa in aqueous solution. The results of computational determination of absolute pKas of arylboronic acids can be very disappointing i...

  • Article
  • Open Access
750 Views
25 Pages

Phase Composition, Structure, and Microwave Absorption of Magnetron-Sputtered Co–C–Cr Multilayer Films

  • Nadezhda Prokhorenkova,
  • Almira Zhilkashinova,
  • Madi Abilev,
  • Leszek Łatka,
  • Igor Ocheredko and
  • Assel Zhilkashinova

Multilayer thin films composed of cobalt (Co), carbon (C), and chromium (Cr) possess promising electromagnetic properties, yet the combined Co–C–Cr system remains underexplored, particularly regarding its performance as a microwave absorb...

of 2

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Compounds - ISSN 2673-6918