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Livers, Volume 4, Issue 2

2024 June - 10 articles

Cover Story: Compensated advanced chronic liver disease (cACLD) represents asymptomatic patients who face the risk of developing clinically significant portal hypertension (CSPH). CSPH, marked by a hepatic venous pressure gradient (HVPG) ≥ 10 mmHg, heralds complications like oesophageal varices, affecting approximately 50% of cirrhosis patients. These varices pose a grave threat due to potential bleeding, which can be fatal. Endoscopic screening, the gold standard for detecting varices, is costly and invasive, highlighting the need for non-invasive tools (NITs). This study focuses on validating and comparing the effectiveness of various NITs, including the Baveno VI criteria (B6C), in an Australian cohort. These NITs offer a promising alternative, potentially alleviating the pressure on endoscopic services by accurately identifying high-risk varices, ensuring timely and effective intervention. View this paper
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Articles (10)

  • Review
  • Open Access
2 Citations
6,605 Views
27 Pages

Exploring the Potential Hepatoprotective Properties of Cactus (Cactaceae) in Liver Health and Disease Management: A Brief Review

  • Anne Caroline Alves Vieira,
  • Fabrícia de Souza Ferreira,
  • Januse Míllia Dantas de Araújo,
  • Larissa Maria Gomes Dutra,
  • Kamila Sabino Batista,
  • Angela Maria Tribuzy de Magalhães Cordeiro and
  • Jailane de Souza Aquino

16 June 2024

Cacti are renowned for their resilience in arid environments and have been utilized as a valuable food source in various cultures for centuries. The potential effects of cactus (Cactaceae) consumption on liver health have garnered significant scienti...

  • Article
  • Open Access
1,578 Views
12 Pages

miRNA Expression and HCC Occurrence in HCV Cirrhotic Patients Treated with Direct Acting Antivirals

  • Antonietta Romano,
  • Alessandra Brocca,
  • Zoe Mariño,
  • Sofía Pérez-del-Pulgar,
  • Sabela Lens,
  • Loreto Boix,
  • María Reig,
  • Jordi Bruix,
  • Giulio Ceolotto and
  • Paolo Angeli
  • + 10 authors

31 May 2024

Background: The risk of hepatocarcinoma in HCV cirrhotic patient responders after treatment with DAAs decrease, but HCC still occurs. A correlation between specific miRNAs and the development of hepatocarcinoma have been highlighted. Aim: To investig...

  • Brief Report
  • Open Access
2 Citations
1,519 Views
7 Pages

Infection-Related Readmissions Are Rising among Patients with Hepatorenal Syndrome: A Nationwide Analysis

  • Umer Farooq,
  • Zahid I. Tarar,
  • Ammad J. Chaudhary,
  • Abdallah E. Alayli,
  • Faisal Kamal,
  • Chengdu Niu and
  • Kamran Qureshi

30 May 2024

Hepatorenal syndrome (HRS) is a unique form of renal dysfunction that results from circulatory hemodynamic dysfunction in advanced liver disease. We aimed to determine longitudinal trends in both all-cause and cause-specific readmissions for HRS in t...

  • Article
  • Open Access
5,712 Views
15 Pages

Understanding the Liver’s Role in the Clearance of Aβ40

  • Glen P. Lockwood,
  • Nicholas J. Hunt,
  • Maaike Kockx,
  • Sun Woo Sophie Kang,
  • David G. Le Couteur and
  • Victoria C. Cogger

23 May 2024

The clearance of peripheral beta amyloid (Aβ) is a potential target for the treatment of Alzheimer’s disease (AD). The liver has been implicated in the elimination of Aβ from the peripheral circulation. Here, the single-pass uptake of...

  • Review
  • Open Access
2 Citations
9,025 Views
13 Pages

Autoimmune Hepatitis Management: Recent Advances and Future Prospects

  • Rebeca Sierra,
  • Ana Marenco-Flores,
  • Marwan Alsaqa,
  • Romelia Barba,
  • Marcela Cuellar-Lobo,
  • Carla Barberan and
  • Leandro Sierra

15 May 2024

Autoimmune hepatitis (AIH) is a varied inflammatory chronic liver disease. AIH’s prevalence varies and has increased recently. Diagnosis involves the discovery of histologic features following liver biopsy and serologic testing. Clinical featur...

  • Article
  • Open Access
3 Citations
2,630 Views
32 Pages

30 April 2024

Many metabolic processes at the molecular level support both viral attack strategies and human defenses during COVID-19. This knowledge is of vital importance in the design of antiviral drugs. In this study, we extracted 18 articles (2021–2023)...

  • Article
  • Open Access
2 Citations
3,814 Views
16 Pages

The Effect of Barley Bran Polyphenol-Rich Extracts on the Development of Nonalcoholic Steatohepatitis in Sprague–Dawley Rats Fed a High-Fat and High-Cholesterol Diet

  • Katsuhisa Omagari,
  • Juna Ishida,
  • Konomi Murata,
  • Ryoko Araki,
  • Mizuki Yogo,
  • Bungo Shirouchi,
  • Kazuhito Suruga,
  • Nobuko Sera,
  • Kazunori Koba and
  • Koichi Tsuneyama
  • + 1 author

24 April 2024

Oxidative stress and inflammation play a central role in the progression of nonalcoholic steatohepatitis (NASH), which can lead to liver cirrhosis. Barley bran has potential bioactivities due to its high content of functional substances, such as anth...

  • Article
  • Open Access
3,127 Views
11 Pages

12 April 2024

Non-invasive tests (NITs) are a potential alternative to screening oesophagogastroduodenoscopy (OGD) for ruling out high-risk varices (HRVs) in patients with compensated advanced chronic liver disease (cACLD). This retrospective study aimed to extern...

  • Review
  • Open Access
17 Citations
10,493 Views
10 Pages

The Epidemiology of Chronic Hepatitis C: Where We Are Now

  • Cristina Stasi,
  • Caterina Milli,
  • Fabio Voller and
  • Caterina Silvestri

30 March 2024

One of the main objectives of the World Health Organization is the eradication of viral hepatitis by 2030 by identifying subjects before disease progression. In 2019, only 21% of the 58 million people chronically infected with hepatitis C virus (HCV)...

  • Case Report
  • Open Access
1 Citations
3,631 Views
8 Pages

Serendipity in Medicine-Elevated Immunoglobulin E Levels Associated with Excess Alcohol Consumption

  • Stephen D. H. Malnick,
  • Ali Abdullah,
  • Fadi Ghanem,
  • Sheral Ohayon Michael and
  • Manuela G. Neuman

25 March 2024

Making a diagnosis of alcoholic liver disease is not always easy. There are problems in obtaining an accurate and reliable history of alcohol consumption. Laboratory findings and hepatic imaging studies are neither sensitive or specific, and newer te...

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Livers - ISSN 2673-4389