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Endocrines, Volume 4, Issue 3

September 2023 - 13 articles

Cover Story: Located within the testicular interstitium, Leydig cells orchestrate the production of testosterone, a pivotal hormone in male health and reproduction. While luteinizing hormone (LH) is the main regulator of Leydig cell steroidogenesis, many other molecules also play key roles, including growth hormone (GH), prolactin (PRL), growth factors (insulin, IGF, FGF, EGF), vitamin D, and osteocalcin. The dynamic interplay between receptors and ligands initiates a series of cascades, modulating the activity of an array of kinases and transcription factors, steroidogenic gene expression, and ultimately, the fine-tuning of testosterone synthesis. View this paper

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Articles (13)

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Review

3 Citations

14,937 Views

15 Pages

Updates on the Management of Hyperglycemia in Hospitalized Adult Patients

Laleh Razavi Nematollahi and
Caitlin Omoregie

Endocrines2023, 4(3), 521-535;https://doi.org/10.3390/endocrines4030037

20 July 2023

The prevalence of diabetes is rising globally; currently, 537 million people worldwide and 37.3 million people in the US are affected. Patients with diabetes have a four-times-greater risk of hospitalization with longer hospital stays and a greater c...

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Review

3,251 Views

19 Pages

Sleep Characteristics in Adults of African Descent at Risk for and with Cardiometabolic Conditions: A Systematic Review

Cherlie Magny-Normilus,
Stephanie Griggs,
Julie Sanders,
Youri Hwang and
Catrina Longhurst

Endocrines2023, 4(3), 502-520;https://doi.org/10.3390/endocrines4030036

19 July 2023

The purpose of this systematic review is to synthesize available studies on sleep health characteristics in adults of African descent with or at risk for cardiometabolic conditions. PubMed, PsycINFO, CINAHL, and Web of Science were searched for origi...

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Article

2,345 Views

14 Pages

Identification of Glucagon Secretion Patterns during an Oral Glucose Tolerance Test

Andrew Shahidehpour,
Mudassir Rashid,
Mohammad Reza Askari,
Mohammad Ahmadasas and
Ali Cinar

Endocrines2023, 4(3), 488-501;https://doi.org/10.3390/endocrines4030035

6 July 2023

Impaired glucagon secretion is a major component of glucose intolerance in type 2 diabetes mellitus (T2D). Glucagon secretion exhibits heterogenous patterns in individuals and across glucose tolerance diagnoses. Characterization of the range of gluca...

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