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Endocrines, Volume 6, Issue 4

2025 December - 8 articles

Cover Story: Adequate sleep plays a crucial role in human health, particularly in cognitive and physiological functions; however, modern lifestyles have led to increased sleep deprivation, associated with health deterioration, including higher incidence of diabetes mellitus and insulin resistance. This review analyzed the relationship between sleep deprivation and insulin resistance, emphasising the metabolic parameters and hormones involved. Overall, the findings consistently showed reduced insulin sensitivity and increased non-esterified fatty acids in sleep-deprived individuals, while hormonal parameters such as cortisol, metanephrines, and normetanephrines showed inconsistent results. While these results support a clear association between sleep deprivation and insulin resistance, further research is needed to clarify the underlying mechanisms. View this paper
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Articles (8)

  • Article
  • Open Access
978 Views
10 Pages

20 November 2025

Background/Objectives: Thyroid dysfunction during pregnancy is associated with a range of adverse perinatal outcomes. This study aims to evaluate the effect of maternal thyroid autoimmunity on selected gestational and perinatal outcomes of the newbor...

  • Review
  • Open Access
825 Views
11 Pages

Diagnosis of Congenital and Acquired Generalized Lipodystrophies—Similarities and Differences

  • Josivan Gomes Lima,
  • Lucas Nobrega Lima,
  • Vitor Yan Bezerra Araujo,
  • Lucia Helena Coelho Nobrega and
  • Julliane Tamara Araújo de Melo Campos

17 November 2025

Generalized lipodystrophies (GLs) are rare diseases characterized by a lack of body fat. When patients with a GL phenotype are referred with a presumptive diagnosis of congenital generalized lipodystrophy (CGL) but genetic testing for known pathogeni...

  • Review
  • Open Access
1 Citations
1,773 Views
13 Pages

For many years, menopause-related bone loss has been attributed solely to declining estrogen levels. Recently it has been suggested that bone loss accelerates during perimenopause, often preceding declines in estradiol (E2), proposing that follicle-s...

  • Feature Paper
  • Review
  • Open Access
1,585 Views
11 Pages

The ovarian corpus luteum has functional mechanisms for formation and regression in the reproductive endocrine system. The main functional events of the corpus luteum are angiogenesis and apoptosis mechanisms. The development of the corpus luteum inv...

  • Article
  • Open Access
2,345 Views
18 Pages

Gestational Weight Gain and Adverse Pregnancy Outcomes in Women with Gestational Diabetes Mellitus and Obesity

  • Filipe Dias de Souza,
  • Patrícia Medici Dualib,
  • Martha Camillo Jordão,
  • Micaela Frasson Montero,
  • Maria Carolina Oliveira Abate,
  • Leonardo Luna,
  • Rosiane Mattar and
  • Bianca de Almeida-Pititto

Background/Objectives: The association between gestational weight gain (GWG) and adverse outcomes in individuals with gestational diabetes mellitus (GDM) and obesity remains unclear. This study aimed to evaluate the relationship between total GWG and...

  • Article
  • Open Access
1,025 Views
18 Pages

Circulating miR-122 and miR-139-3p: Association with Lipid, Inflammatory, and Glycemic Profile in Adolescents with Insulin-Resistant and Overweight

  • Tanyara Baliani Payolla,
  • Paula Nascimento Brandão-Lima,
  • Gabrielli Barbosa de Carvalho,
  • Flávia Mori Sarti,
  • Regina Mara Fisberg and
  • Marcelo Macedo Rogero

Background/Objectives: Insulin resistance (IR) in adolescents contributes to the development of metabolic and immunological alterations. These alterations can lead to chronic, systemic, low-grade inflammation in adulthood. Evidence suggests that alte...

  • Article
  • Open Access
1,073 Views
10 Pages

Obesity Is Associated with Larger Thyroid Nodules but Not with Malignant Cytology

  • Stefania Giuliano,
  • Giuseppe Seminara,
  • Stefano Iuliano,
  • Stefania Obiso,
  • Eusebio Chiefari,
  • Daniela P. Foti,
  • Maria Mirabelli and
  • Antonio Brunetti

Background: Obesity has been proposed as a risk factor for differentiated thyroid carcinoma (DTC), though findings in the literature remain conflicting. While some studies suggest an association between elevated body mass index (BMI) and thyroid mali...

  • Review
  • Open Access
2 Citations
9,460 Views
27 Pages

Sleep Deprivation and Its Impact on Insulin Resistance

  • Margarida C. Pinheiro,
  • Henrique E. Costa,
  • Melissa Mariana and
  • Elisa Cairrao

Background/Objectives: Adequate sleep has a fundamental role in human health, mainly in cognitive and physiological functions. However, the daily demands of modern society have led to a constant pursuit of better living conditions, requiring more act...

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Endocrines - ISSN 2673-396X